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1978 (1)
1976 (1)
1Author    H.E JRequires cookie*
 Title    Synthetic Studies towards anti-Leukaemic Alkaloids, VIII The Roads to Vinblastine ATTA-UR-RAHMAN, ANWER BASHA, MARYAM GHAZALA, and NIGHAT WAHEED  
 Abstract    Various synthetic approaches to the anti-cancer alkaloids vinblastine and vincristine are described. Methods for the generation of nine-membered nitrogen containing rings present in the indole moiety of vinblastine are discussed. Modes of joining the two moieties present in VLB in a natural configuration are presented. 
  Reference    (Z. Naturforsch. 31b, 1416—1420 [1976]; received April 28 1976) 
  Published    1976 
  Keywords    anti-Cancer, Alkaloids, Vinblastine, Vincristine 
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 TEI-XML for    default:Reihe_B/31/ZNB-1976-31b-1416.pdf 
 Identifier    ZNB-1976-31b-1416 
 Volume    31 
2Author    Atta-Ur-Rahman, Sadiqa Firdous, Anwer BashaRequires cookie*
 Title    Alkaloids, IX* Some Aspects of the Chemistry of C atliar anthine  
 Abstract    Vinblastine and Vincristine are binary indole-indoline alkaloids occurring in traces in the leaves of Vinca rosea. They are among the most powerful chemotherapeutic agents available to man for the treatment of a variety of cancers. Their high cost and complexity of structure has attracted the attention of many eminent chemists towards their synthesis. The first synthesis of both these anta'-tumour alkaloids was reported by us last year [7] starting from two major alkaloids, catharanthine and vindo-line, which co-occur in the same plant. Some aspects of the chemistry of catharanthine are now presented including a novel one-step de-carbomethoxylation reaction with H2S in glacial acetic acid and a reversible isomerization of catharanthine with sodium borohydride. A study of the life-time of catharanthine in hot glacial acetic acid substantiates the earlier work of the Anglo-French group on the biosynthesis of indole alkaloids. 
  Reference    Z. Naturforsch. 33b, 469—470 (1978); received December 5 1977 
  Published    1978 
  Keywords    Vinblastine, Vincristine, Decarbomethoxylation, anti-Cancer Drugs, Indole Alkaloids 
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 TEI-XML for    default:Reihe_B/33/ZNB-1978-33b-0469_n.pdf 
 Identifier    ZNB-1978-33b-0469_n 
 Volume    33