| | 1 | Author
| PetiaA. Dimitrova3, RenetaA. Toshkovab, EmiliaH. Ivanova3, ZvetankaH. Stefanova3, MariaB. Angelova3, PavlinaA. Dolashkac, W. Voelterd | Requires cookie* | | | Title
| Superoxide Production by Phagocytes in Myeloid Graffi Tumor-Bearing Hamsters  | | | | Abstract
| A progressive suppression of the phagocytic ability of peritoneal macrophages and poly-morphonuclears (PMNs) in hamsters with transplanted myeloid tumors was previously estab lished. The i.p. application of Cu/Zn SOD, isolated from the fungal strain Humicola lutea (H LSO D) (2 injections before and 5 injections after tumor transplantation) induced the mean survival time of the animals as well as a temporally stimulating action on the macro phage and PMNs phagocyting indices. In the present work, the superoxide production of peritoneal macrophages and PMNs during 30 days of tumor progression was followed. Effects of the application of H LSO D in an optimal protective dose on the superoxide production in peritoneal macrophages and blood PMNs were examined. The spontaneous and phorbol-myristate acetate (PMA)-inducible 0 2~ production in both types of phagocytes was 4-5-fold increased in tumor-bearing hamsters (TBH), as compared to the controls, at day 14 after tumor transplantation (the day of tumor appearance in transplanted animals). Furthermore, 0 2~ production was also similar to the control values for the following days of observation. H LSO D treatment of TBH induced a normalization of superoxide production in macro phages and PMNs. Therefore, the established decrease of superoxide anions in phagocyting cells of TBH indicates possible effects of HLSOD on the host antioxidant defense. | | | |
Reference
| Z. Naturforsch. 55c, 799—805 (2000); received April 19/May 19 2000 | | | |
Published
| 2000 | | | |
Keywords
| Superoxide Dismutase, Macrophages, Tumors | | | |
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| default:Reihe_C/55/ZNC-2000-55c-0799.pdf | | | | Identifier
| ZNC-2000-55c-0799 | | | | Volume
| 55 | |
| 2 | Author
| E. Schauenstein, J. Gölles, H. W. Altersdorf Er, R. J. Sdiaur | Requires cookie* | | | Title
| Association between the Doubling Time of Various Cells and Tissues, and the SH-Content of Their Soluble Proteins | | | | Abstract
| The num ber of SH-groups of the soluble proteins (Prot-SH) of 12 different types of animal tum ors and of cultivated chicken fibroblasts increases with decreasing doubling tim e (id) ■ Between Prot-SH and id an inverse association was found with a significance level of 99.5%. After 30 min incubation in vitro, 4-hydroxypentenal (H PE) reacts with different am ounts of the Prot-SH of the investigated cells and tissues. It was found that the absolute, as well as the per cental amounts of HPE-reactive Prot-SH increase with decreasing fd > each of the respective inverse associations was found to be highly significant. The tum ors were collected in three groups, each with a corresponding range of td and a mean value for Prot-SH . Taking the Prot-SH of the slowest growing tissue (DENA-hepatoma) as the reference value, the increm ents of Prot-SH were cal culated for each of the three groups and were found to be strikingly sim ilar to the num ber of HPE-reactive Prot-SH. The single Prot-SH increm ents of the diverse cell and tissue types compared with DENA-hepatoma were found to be highly significantly and inversely associated with the respective Prot-SH decreases caused by H PE. Hence it may be concluded that H PE reacts preferably with those of the Prot-SH which are of some functional importance for tum or growth and, moreover that the attack on those thiols is the more effective the faster the tumor is growing. | | | |
Reference
| Z. Naturforsch. 33c, 79 (1978); received A pril 5/O ctober 24 1977 | | | |
Published
| 1978 | | | |
Keywords
| Protein-SH-Groups, Tumors, Doubling Time | | | |
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| default:Reihe_C/33/ZNC-1978-33c-0079.pdf | | | | Identifier
| ZNC-1978-33c-0079 | | | | Volume
| 33 | |
| 4 | Author
| FrancisJ. Bonner, Lars-Olof Sundelöf | Requires cookie* | | | Title
| Thermal Diffusion as a Mechanism for Biological Transport | | | | Abstract
| Accumulated experimental information is used to assess the possible significance o f thermal diffusion to mass transport in living matter. Possible thermal gradients across m em branes, a single living cell, and an ensem ble o f such cells (e.g. an organ, tumor, etc.) are estim ated. The corresponding model calculations, although not describing the biological process in detail, lead to conclusions about the possibilities for thermal diffusion as follows. A dequate thermal gradients to support substantial thermal diffusion could exist across biological m embranes. Thermal diffusive flow would becom e significant when ordinary Fickian diffusion is sufficiently sup pressed, e.g. in more concentrated systems near critical points o f solution (i.e. near incipient phase separations). Conditions favorable to thermal diffusion functioning as a m echanism for active transport appear possible. Thermal diffusion appears much m ore im portant for transport into and out o f an ensemble o f cells than into or out o f a single cell. Such mass transport by thermal diffusion could assume a sizable m agnitude for an ensem ble o f cells with the dim ensions o f an organ or a tumor. | | | |
Reference
| Z. Naturforsch. 39c, 656 (1984); received October 14 1980/N ovem ber 23 1983 | | | |
Published
| 1984 | | | |
Keywords
| Thermal Diffusion, Biological Transport, M embranes, Organs, Tumors | | | |
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| default:Reihe_C/39/ZNC-1984-39c-0656.pdf | | | | Identifier
| ZNC-1984-39c-0656 | | | | Volume
| 39 | |
| 5 | Author
| Lars Schaade3, KlausR. Reiner Thomssenb, Itter3 | Requires cookie* | | | Title
| Differentiation in Murine Mastocytoma Induced by Macrophage Gangliosides | | | | Abstract
| In the membrane of mouse macrophages two gangliosides were detected which inhibit the division of murine mastocytoma P815 tum or cells. The two gangliosides were incorporated into the cytoplasmatic membrane of mastocytoma cells. The concentration necessary to achieve a complete inhibition of P815 tum or cell division is about 1 [_ im for both effective gangliosides. Macrophage ganglioside-induced inhibition of cell division is accompanied by morphological changes of the mastocytoma cells. While the cells are rounding, their diameter increases and serotonin and granules appear in the cytoplasm of the enlarged cells. O ur findings suggest that macrophage gangliosides may differentiate mastocytoma cells into mast cells. | | | |
Reference
| Z. Naturforsch. 55c, 1004—1010 (2000); received May ll/Ju ly 7 2000 | | | |
Published
| 2000 | | | |
Keywords
| Gangliosides, Tumor, Growth A rrest | | | |
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| default:Reihe_C/55/ZNC-2000-55c-1004.pdf | | | | Identifier
| ZNC-2000-55c-1004 | | | | Volume
| 55 | |
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