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1Author    PetiaA. Dimitrova3, RenetaA. Toshkovab, EmiliaH. Ivanova3, ZvetankaH. Stefanova3, MariaB. Angelova3, PavlinaA. Dolashkac, W. VoelterdRequires cookie*
 Title    Superoxide Production by Phagocytes in Myeloid Graffi Tumor-Bearing Hamsters  
 Abstract    A progressive suppression of the phagocytic ability of peritoneal macrophages and poly-morphonuclears (PMNs) in hamsters with transplanted myeloid tumors was previously estab­ lished. The i.p. application of Cu/Zn SOD, isolated from the fungal strain Humicola lutea (H LSO D) (2 injections before and 5 injections after tumor transplantation) induced the mean survival time of the animals as well as a temporally stimulating action on the macro­ phage and PMNs phagocyting indices. In the present work, the superoxide production of peritoneal macrophages and PMNs during 30 days of tumor progression was followed. Effects of the application of H LSO D in an optimal protective dose on the superoxide production in peritoneal macrophages and blood PMNs were examined. The spontaneous and phorbol-myristate acetate (PMA)-inducible 0 2~ production in both types of phagocytes was 4-5-fold increased in tumor-bearing hamsters (TBH), as compared to the controls, at day 14 after tumor transplantation (the day of tumor appearance in transplanted animals). Furthermore, 0 2~ production was also similar to the control values for the following days of observation. H LSO D treatment of TBH induced a normalization of superoxide production in macro­ phages and PMNs. Therefore, the established decrease of superoxide anions in phagocyting cells of TBH indicates possible effects of HLSOD on the host antioxidant defense. 
  Reference    Z. Naturforsch. 55c, 799—805 (2000); received April 19/May 19 2000 
  Published    2000 
  Keywords    Superoxide Dismutase, Macrophages, Tumors 
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 TEI-XML for    default:Reihe_C/55/ZNC-2000-55c-0799.pdf 
 Identifier    ZNC-2000-55c-0799 
 Volume    55 
2Author    E. Schauenstein, J. Gölles, H. W. Altersdorf Er, R. J. SdiaurRequires cookie*
 Title    Association between the Doubling Time of Various Cells and Tissues, and the SH-Content of Their Soluble Proteins  
 Abstract    The num ber of SH-groups of the soluble proteins (Prot-SH) of 12 different types of animal tum ors and of cultivated chicken fibroblasts increases with decreasing doubling tim e (id) ■ Between Prot-SH and id an inverse association was found with a significance level of 99.5%. After 30 min incubation in vitro, 4-hydroxypentenal (H PE) reacts with different am ounts of the Prot-SH of the investigated cells and tissues. It was found that the absolute, as well as the per­ cental amounts of HPE-reactive Prot-SH increase with decreasing fd > each of the respective inverse associations was found to be highly significant. The tum ors were collected in three groups, each with a corresponding range of td and a mean value for Prot-SH . Taking the Prot-SH of the slowest growing tissue (DENA-hepatoma) as the reference value, the increm ents of Prot-SH were cal­ culated for each of the three groups and were found to be strikingly sim ilar to the num ber of HPE-reactive Prot-SH. The single Prot-SH increm ents of the diverse cell and tissue types compared with DENA-hepatoma were found to be highly significantly and inversely associated with the respective Prot-SH decreases caused by H PE. Hence it may be concluded that H PE reacts preferably with those of the Prot-SH which are of some functional importance for tum or growth and, moreover that the attack on those thiols is the more effective the faster the tumor is growing. 
  Reference    Z. Naturforsch. 33c, 79 (1978); received A pril 5/O ctober 24 1977 
  Published    1978 
  Keywords    Protein-SH-Groups, Tumors, Doubling Time 
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 TEI-XML for    default:Reihe_C/33/ZNC-1978-33c-0079.pdf 
 Identifier    ZNC-1978-33c-0079 
 Volume    33 
3Author    W. SchäferRequires cookie*
 Title    Der Mäuse-Inzuchtstamm STU. Entwicklung und Eigenschaften The Inbred Mouse Strain STU. Development and Properties  
 Abstract    The highly inbred STU mouse strain (up to 100 inbred generations) was developed from a German white mouse colony. Its properties are described with special emphasis on the occurrence of tumors, occurrence of C-type oncorna­ viruses and on its immunological reactivity. The predominant tumor is a fibrosarcoma (~23% incidence). 
  Reference    Z. Naturforsch. 34c, 306—309 (1979); eingegangen am 7. Februar 1979 
  Published    1979 
  Keywords    Inbred Mice, Tumors, Oncorna Viruses, Immunological Reactivity 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-0306_n.pdf 
 Identifier    ZNC-1979-34c-0306_n 
 Volume    34 
4Author    FrancisJ. Bonner, Lars-Olof SundelöfRequires cookie*
 Title    Thermal Diffusion as a Mechanism for Biological Transport  
 Abstract    Accumulated experimental information is used to assess the possible significance o f thermal diffusion to mass transport in living matter. Possible thermal gradients across m em branes, a single living cell, and an ensem ble o f such cells (e.g. an organ, tumor, etc.) are estim ated. The corresponding model calculations, although not describing the biological process in detail, lead to conclusions about the possibilities for thermal diffusion as follows. A dequate thermal gradients to support substantial thermal diffusion could exist across biological m embranes. Thermal diffusive flow would becom e significant when ordinary Fickian diffusion is sufficiently sup­ pressed, e.g. in more concentrated systems near critical points o f solution (i.e. near incipient phase separations). Conditions favorable to thermal diffusion functioning as a m echanism for active transport appear possible. Thermal diffusion appears much m ore im portant for transport into and out o f an ensemble o f cells than into or out o f a single cell. Such mass transport by thermal diffusion could assume a sizable m agnitude for an ensem ble o f cells with the dim ensions o f an organ or a tumor. 
  Reference    Z. Naturforsch. 39c, 656 (1984); received October 14 1980/N ovem ber 23 1983 
  Published    1984 
  Keywords    Thermal Diffusion, Biological Transport, M embranes, Organs, Tumors 
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 TEI-XML for    default:Reihe_C/39/ZNC-1984-39c-0656.pdf 
 Identifier    ZNC-1984-39c-0656 
 Volume    39 
5Author    Lars Schaade3, KlausR. Reiner Thomssenb, Itter3Requires cookie*
 Title    Differentiation in Murine Mastocytoma Induced by Macrophage Gangliosides  
 Abstract    In the membrane of mouse macrophages two gangliosides were detected which inhibit the division of murine mastocytoma P815 tum or cells. The two gangliosides were incorporated into the cytoplasmatic membrane of mastocytoma cells. The concentration necessary to achieve a complete inhibition of P815 tum or cell division is about 1 [_ im for both effective gangliosides. Macrophage ganglioside-induced inhibition of cell division is accompanied by morphological changes of the mastocytoma cells. While the cells are rounding, their diameter increases and serotonin and granules appear in the cytoplasm of the enlarged cells. O ur findings suggest that macrophage gangliosides may differentiate mastocytoma cells into mast cells. 
  Reference    Z. Naturforsch. 55c, 1004—1010 (2000); received May ll/Ju ly 7 2000 
  Published    2000 
  Keywords    Gangliosides, Tumor, Growth A rrest 
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 TEI-XML for    default:Reihe_C/55/ZNC-2000-55c-1004.pdf 
 Identifier    ZNC-2000-55c-1004 
 Volume    55