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1997 (1)
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1Author    Ping-Lu LiRequires cookie*
 Title    Cytotoxicity of Cobra (Naja naja kaouthia) Venom on Rabbit Red Blood Cells and S-180 Tumor Cells in the Presence of Tetracaine, Lidocaine and Procaine  
 Abstract    The cytocidal action of Naja naja kaouthia venom on rabbit red blood cells and S-180 tumor cells treated with local anesthetics (tetracaine, lidocaine and procaine) were studied. The S-180 cells were more sensitive to the venom than the red blood cells which required albumin for ef­ ficient hemolysis in the 10 minute assay. All three local anesthetics at lower concentrations protected both cell types against venom hemolysis. At higher concentrations the local anesthetics enhanced the cell lysis to 100%. The effectiveness of the local anesthetics for both the inhibition and enhancement phases of cytotoxicity was tetracaine > lidocaine > procaine. This is the same order as their anesthetic effectiveness, lipid solubility and their protein binding. 
  Reference    Z. Naturforsch. 35c, 268 (1980); received October 8 1979 
  Published    1980 
  Keywords    Local Anesthetics, Cobra Venom, Cytotoxicity, Erythrocytes, Tumor Cells 
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 TEI-XML for    default:Reihe_C/35/ZNC-1980-35c-0268.pdf 
 Identifier    ZNC-1980-35c-0268 
 Volume    35 
2Author    M. Wenzel, Y. Wu, E. Liss, E. W. NeuseRequires cookie*
 Title    Stabilität des Ferricinium-Kations und seine cytostatische Wirkung Stability of Ferricinium and its Cytostatic Effect  
 Abstract    The relative stabilities of different ferricinium cations were studied in buffer or serum-containing solution and in vivo and compared with their cytostatic effects in cultures of Yoshida ascites tumor cells. Although the ferricinium cation itself was the most un-stable cation compared with the dimethyl-ferricinium ca-tion and the deuterated ferricinium derivatives it showed the highest cytostatic effect. 
  Reference    Z. Naturforsch. 43c, 963—966 (1988); received April 5 1988 
  Published    1988 
  Keywords    Ferricinium, Dimethyl-ferricinium, Deuterium, Tumor Cells, Cytostatic Effect 
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 TEI-XML for    default:Reihe_C/43/ZNC-1988-43c-0963_n.pdf 
 Identifier    ZNC-1988-43c-0963_n 
 Volume    43 
3Author    TetsuyaM. AtsunoRequires cookie*
 Title    A New Clerodane Diterpenoid Isolated from Propolis  
 Abstract    A physiologically active substance has been isolated from Brazilian propolis and charac­ terized as a new clerodane diterpenoid, as indicated by human hepatocellular carcinoma HuH 13 cell cytotoxicity assays. This compound inhibited growth of the hepatom a cells at a concentration around 10 [ig/ml and arrested the tumor cells at S phase as revealed by flow cytometry. A t higher concentrations it exerted lethal damage. The compound showed cyto­ toxicity on human lung carcinoma HLC-2, HeLa, KB and rat W 3 Y cells, whereas human diploid foreskin and primary rabbit kidney cells were less affected. 
  Reference    Z. Naturforsch. 50c, 93—9 (1995); received August 5/October 18 1994 
  Published    1995 
  Keywords    Propolis, Clerodane D iterpenoid, Tumor Cells, Flow Cytometry, Colcemid, Cytotoxicity 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0093.pdf 
 Identifier    ZNC-1995-50c-0093 
 Volume    50 
4Author    TetsuyaM. Atsuno3, YasuyukiM. Atsum Otob, Masahiro Saitob, JunjiM. OrikawabRequires cookie*
 Title    Isolation and Characterization of Cytotoxic Diterpenoid Isomers from Propolis  
 Abstract    The methanol extract of Brazilian propolis was frac­ tionated by HPLC, based on HuH13 (human hepatocel­ lular carcinoma) cell cytotoxicity assay. Two isomers of diterpenoid with a molecular formula of C20H 30O 3 (MW: 318.46) were isolated. The structures of these colorless compounds were determined as clerodane diterpenoids (I, 15-oxo-3, 13Z-kolavadien-17-oic acid; II, 15-oxo-3Z, ISf-kolavadien-n-oic acid). 
  Reference    Z. Naturforsch. 52c, 702—704 (1997); received March 27/May 12 1997 
  Published    1997 
  Keywords    Propolis, Clerodane Diterpenoid, N aphthalene Carbox-ylic Acid Derivative, Tumor Cells, Cytotoxicity 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0702_n.pdf 
 Identifier    ZNC-1997-52c-0702_n 
 Volume    52