| 1 | Author | W. Ilhelm Hasselbach, Hans Liidi, Andrea Migala | Requires cookie* |
| Title | Inactivation o f the Sarcoplasm ic Reticulum C alcium -Transport-A TPase by L asolocid in Com bination with Triton X-100  | ||
| Abstract | The calcium-transport-ATPase of the sarcoplasmic reti culum membranes is irreversibly inactivated by the com bined action of Lasolocid and Triton X-100 at concentra tions which separately do not interfere with the enzyme's activity. In the presence of Lasolocid the enzyme is most susceptable to inactivation when the Triton X-100 concen tration just exceeds its critical micellar concentration, ~ 0.2 mg • ml-1. Lasolocid becomes effective at a concentra tion of 10 (jm and produces rapid inactivation at 100 |jm . The enzyme is more rapidly inactivated in the active than in the inactive state. | ||
| Reference | Z. Naturforsch. 37c, 1290—1292 (1982); received October 28 1982 | ||
| Published | 1982 | ||
| Keywords | Calcium-Transport-ATPase, Sarcoplasmic Reticulum, Calcium-Ionophores, Triton X-100 | ||
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