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1987 (1)
1Author    M. Ark, P. Staves, DavidP. BlochRequires cookie*
 Title    Evolution of E. coli tRNAI,e: Evidence of Derivation from Other tRNAs  
 Abstract    Two E. coli tR N A Ile sequences were com pared against those of 36 other E. coli tRN As. tR N A Ile 1 was found to bear high similarity with tR N A Val 1 (E = 1.11 x 10" 18) while tR N A Ile 2 had the greatest match (£ = 3 .4 0 x 10" 19) with tR N A Lysl (E is the expected num ber of such matches, per search, based on coincidence). These m atches, which we consider to represent homologies, extend from base 7 to base 67 in the form er and base 7 to the end (76) in the latter pair. These results coupled wim otners on tne lower activity ot isoleucine in reactions postulated to be im portant in primitive protein synthesis (i.e. esterification reactions and non-enzym atic activation by A TP [1—3]) lead us to propose that isoleucine was included among the proteinaceous amino acids, and received its anticodonic assignment, relatively late in evolution through m utation of tR N A s previously employed for other amino acids. 
  Reference    Z. Naturforsch. 42c, 129 (1987); received June 13/September 4 1986 
  Published    1987 
  Keywords    Transfer R N A, Evolution, Codon Assignments, Sequence Homology, Hydrophobicity 
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 TEI-XML for    default:Reihe_C/42/ZNC-1987-42c-0129.pdf 
 Identifier    ZNC-1987-42c-0129 
 Volume    42