| | 1 | Author
| M. Ark, P. Staves, DavidP. Bloch | Requires cookie* | | | Title
| Evolution of E. coli tRNAI,e: Evidence of Derivation from Other tRNAs  | | | | Abstract
| Two E. coli tR N A Ile sequences were com pared against those of 36 other E. coli tRN As. tR N A Ile 1 was found to bear high similarity with tR N A Val 1 (E = 1.11 x 10" 18) while tR N A Ile 2 had the greatest match (£ = 3 .4 0 x 10" 19) with tR N A Lysl (E is the expected num ber of such matches, per search, based on coincidence). These m atches, which we consider to represent homologies, extend from base 7 to base 67 in the form er and base 7 to the end (76) in the latter pair. These results coupled wim otners on tne lower activity ot isoleucine in reactions postulated to be im portant in primitive protein synthesis (i.e. esterification reactions and non-enzym atic activation by A TP [1—3]) lead us to propose that isoleucine was included among the proteinaceous amino acids, and received its anticodonic assignment, relatively late in evolution through m utation of tR N A s previously employed for other amino acids. | | | |
Reference
| Z. Naturforsch. 42c, 129 (1987); received June 13/September 4 1986 | | | |
Published
| 1987 | | | |
Keywords
| Transfer R N A, Evolution, Codon Assignments, Sequence Homology, Hydrophobicity | | | |
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| default:Reihe_C/42/ZNC-1987-42c-0129.pdf | | | | Identifier
| ZNC-1987-42c-0129 | | | | Volume
| 42 | |
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