| 1 | Author | Wolfgang Heinzel, Thomas Kronbach, Wolfgang Voelter | Requires cookie* |
| Title | Klassische Synthese von Thymopoietin 32-36 (TP 5) unter Verwendung der säurelabilen 1-(1 -Adamantyl) -1 -methylethoxycarbonyl-Schutzgruppe + Conventional Synthesis of Thymopoietin 32-36 (TP 5) Using the 1 -(1 -Adamantyl)-1 -methylethoxycarbonyl Group +  | ||
| Abstract | A synthesis of high yields of TP 5 is described. The a-amino functions were blocked by the acid-labile 1-(1 -adamantyl)-l-methylethoxycarbonyl-(Adpoc)group. The Adpoc group is cleaved under mild acidolytic conditions with 3% TFA in CH2CI2 while the £er<-butyl residues remained intact. This selective cleavage of the Adpoc group compared with the Boc and £er£-butyl residues allows new strategies for the synthesis of large peptides. | ||
| Reference | Z. Naturforsch. 37b, 1652—1658 (1982); eingegangen am 16. September 1982 | ||
| Published | 1982 | ||
| Keywords | Adpoc, Amino Acids, Thymopoietin | ||
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