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'Thymidine' in keywords
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1976 (1)
1Author    Paul PeringerRequires cookie*
 Title    N-Organoquecksilber-Nucleoside N-Organomercury Nucleosides  
 Abstract    The synthesis of the N-organomercury nucleosides CßHsHgL (LH = guanosine, inosine, thymidine, uridine) is described. 
  Reference    Z. Naturforsch. 34b, 1459—1460 (1979); eingegangen am 2. Mai/6. Juli 1979 
  Published    1979 
  Keywords    Organomercury, Guanosine, Inosine, Thymidine, Uridine 
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 TEI-XML for    default:Reihe_B/34/ZNB-1979-34b-1459_n.pdf 
 Identifier    ZNB-1979-34b-1459_n 
 Volume    34 
2Author    Mibal Dizdaroglu, Klaus Neuwald, ClemensVon SonntagRequires cookie*
 Title    Radiation Chemistry of DNA Model Compounds, IX* Carbohydrate Products in the y-Radiolysis of Thymidine in Aqueous Solution. The Radical-Induced Scission of the N-Glycosidic Bond  
 Abstract    In the y-radiolysis of deoxygenated N20-saturated aqueous solutions of thymidine (10-3 M, room temperature, dose rate 4 • 10 18 eV/g.h., dose 6.7 10 17 -3.3 • 10 18 eV/g) the following products (G-values in parentheses) have been identified: 2,5-dideoxy-pentos-4-ulose (1) (0.01), 2,4-dideoxy-pentodialdose (2) (0.02), 2,4-dideoxy-pentos-3-ulose (3) (0.03), 2,3-dideoxy-pentos-4-ulose (4) (0.01), 2-deoxy-pentos-4-ulose (5) (0.1), 2-deoxy-ribonic acid (6) (0.02) and thymine (8) (< 0.2). In the presence of oxygen (N20/02 80/20 v/v saturated) products 1-4 are absent, G (5) = 0.2, G (6) = 0.07 and G (8) < 0.4. Further-more, 2-deoxy-tetrodialdose (7) which is absent in deoxygenated solution is formed with a G-value of 0.03. Mechanisms are proposed to account for the scission of the N-glycosidic linkage. Product 6 is thought to be due to a primary OH radical attack at C-l' of the sugar moiety, 3 arises from an attack at C-3', 1, 4 and 5 from an attack at C-4', and 2 and 7 from an attack at C-5'. 
  Reference    (Z. Naturforsch. 31b, 227—233 [1976]; received September 24 1975) 
  Published    1976 
  Keywords    Thymidine, Radiolysis, Radical Reactions, GC-MS, DNA Model Compounds 
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 TEI-XML for    default:Reihe_B/31/ZNB-1976-31b-0227.pdf 
 Identifier    ZNB-1976-31b-0227 
 Volume    31 
3Author    IvankaG. Stankova3, M. Ario, F. Simeonovb, Vera Maximova0, AngelS. Galabov0, EvgenyV. GolovinskydRequires cookie*
 Title    Synthesis and Anti-Virus Activity of Some Nucleosides Analogues  
 Abstract    New 3'-, 5'-, 5-bromo-2'-deoxyuridine (3 a -g) and 3'-, 5'-thymidine (4 a -i) analogues with amino acid and peptide residues were synthesized and evaluated for antiviral activity. The influence of long peptide chains, essential amino acids and the effect of this structural modifi­ cation on the antiviral activity has been also reported. Three 5-bromo-2'-deoxyuridine derivatives containing glycyl-, glycyl-glycyl-and glycyl-gly-cyl-glycyl-residues (3a, 3b, 3c) showed a strong activity against the herpes virus PsRV and a moderate one vs. HSV-1. The corresponding thymidine analogues were considerably less effective, and only com­ pounds 4d and 4h showed a borderline effect against PsRV. 
  Reference    Z. Naturforsch. 54c, 75—83 (1999); received August lO/October 20 1998 
  Published    1999 
  Keywords    5-Bromo-2'-Deoxyuridine, Thymidine, Amino Acids, Peptides, Antiherpes Activity 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0075.pdf 
 Identifier    ZNC-1999-54c-0075 
 Volume    54