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'Synthetic Derivative' in keywords Facet   Publication Year 1999  [X]
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1Author    Nikos Mihopoulosac, Constantinos Vagias3, Ioanna Chinou3, Christos Roussakisb, Michael Scoullosc, Catherine Harvala3, Vassilios Roussis3Requires cookie*
 Title    Antibacterial and Cytotoxic Natural and Synthesized Hydroquinones from Sponge Ircinia spinosula  
 Abstract    In order to check the structure-activity relationship and find more potent derivatives of the natural products 1 and 2 obtained from sponge Ircinia spinosula, a series of oxidation, hydrogenation, acetylation and methylation derivatives was prepared. All compounds (natu­ ral and synthetic ones) were screened for their cytotoxic and antibacterial activities. The biological studies showed a wide range of antibacterial activity even though only 2 and 2d showed a moderate cytotoxicity against the clone C98. The oxidation of the hydroquinone to quinone and the hydrogenation of the side-chain increased the antibacterial effect of the molecules. 
  Reference    Z. Naturforsch. 54c, 417 (1999); received January 29/March 9 1999 
  Published    1999 
  Keywords    Ircinia spinosula, Polyprenylated Hydroquinone, Synthetic Derivative, Antitumoral Activity, Antibacterial Activity 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0417.pdf 
 Identifier    ZNC-1999-54c-0417 
 Volume    54