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1974 (1)
1Author    Frank Seela, Wolfgang WesemannRequires cookie*
 Title    Trägergebundene Serotoninderivate und Affinitätschromatographie synaptischer Membranproteine Resin Linked Derivatives of Serotonin and Affinity Chromatography of Proteins Isolated from Synaptic Membranes  
 Abstract    An affinity resin for the isolation of the serotonin receptor from nerve ending membranes was prepared by coupling tryptamine, 5-methoxy-tryptamine or serotonin to CNBr-activated Sepharose 4 B. The tryptamine derivatives, N-6-(aminohexyl)-tryptamines, were obtained by subsequent con­ densation of the corresponding indole derivatives with oxalyl chloride and t-aminocaproamide and reduction with L iA lH 4 . The 6-aminohexyl-group was used as spacer to link covalently the primary amino-group of tryptamine to agarose. — An extract of membrane proteins isolated from rat brain was resolved on this affinity resin into two fractions as compared with only one fraction using unsubstituted Sepharose 4 B. 
  Reference    (Z. Naturforsch. 29c, 248—256 [1974]; eingegangen am 2. Januar/15. Februar 1974) 
  Published    1974 
  Keywords    Affinity Chromatography, Receptor, Resin Linked Serotonin, Synaptic Membrane Proteins 
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 TEI-XML for    default:Reihe_C/29/ZNC-1974-29c-0248.pdf 
 Identifier    ZNC-1974-29c-0248 
 Volume    29