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'Structure activity relationship' in keywords Facet   section ZfN Section C:Volume 039  [X]
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1984 (2)
1Author    Berg, M. Arjo, Brandse Duphar, B. V. BiochemistryRequires cookie*
 Title    G erard van den  
 Abstract    The effects of the algicide PH 40-62 on photosynthetic reactions in spinach chloroplasts were studied. The compound proved to be an uncoupler o f photophosphorylation, whereas inhibition of photosynthetic electron transport occurred at higher concentrations. The site of this inhibition was before photosystem II. The uncoupling effect was partially reversible. In a series o f related compounds the uncoupling activity appeared mainly dependent on the lipophilic properties o f the compounds but electronic effects also played a distinct role. C om paring these uncoupling data with those of some known series of uncouplers it appeared that lipophilicity determ ines the uncoupling activity in an identical way and a regression equation was found describing the uncoupling activities of 60 compounds belonging to four chemically different groups of com ­ pounds. 
  Reference    Z. Naturforsch. 39c, 107—114 (1984); received Septem ber 19 1983 
  Published    1984 
  Keywords    Arylethanediamines, Photophosphorylation, U ncouplers, Structure-Activity Relationships 
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 TEI-XML for    default:Reihe_C/39/ZNC-1984-39c-0107.pdf 
 Identifier    ZNC-1984-39c-0107 
 Volume    39 
2Author    HermannL. LotterRequires cookie*
 Title    Untersuchung der Struktur-Wirkungsbeziehung antihepatotoxischer Naturstoffe (Silybin-Antamanid) durch Röntgenstrukturanalyse  
 Abstract    Both, the flavonolignane silybin and the decapeptide antam anide, protect anim als against the mushroom poison phalloidin from Amanita species. The X-ray structures o f silybin and anta­ manide have been solved in previous studies. Here an attempt has been m ade to explain the antagonistic antihepatotoxic protection by sim ilar chem ical structure elem ents in the two compounds. It can be shown that two aromatic rings in a definite arrangement are essential for the attachment to the target structure o f the liver cell membrane. Com parable pharm acological tests are discussed. 
  Reference    Z. Naturforsch. 39c, 535 (1984); received Decem ber 2 1983/March 26 1984 
  Published    1984 
  Keywords    Silybin, Antamanide, Phalloidin, Structure Activity Relationship, A ntihepatotoxic Principle 
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 TEI-XML for    default:Reihe_C/39/ZNC-1984-39c-0535.pdf 
 Identifier    ZNC-1984-39c-0535 
 Volume    39