| | 1 | Author
| Bernd Sorg, Michael Gschwendt, HeinzWalter Thielmann, Erich Hecker | Requires cookie* | | | Title
| Struktur-Wirkungsbeziehungen polyfunktioneller Diterpene des Tigliantyps, IV [1-3] Structure-Activity Relationships of Polyfunctional Diterpenes of the Tigliane Type, IV [1-3] Derivatives of Tigliane without or with Opened Cyclopropane Ring and their Irritant and Promoting Activity  | | | | Abstract
| Derivate des Tiglians mit fehlendem oder geöffnetem Cyclopropanring und ihre irritierende und tumorpromovierende Wirkung The synthesis of the esters 6d-8d, 9 c and 10 c is described. These compounds are closely structurally related to the irritant and tumorpromoting 12-0-tetradecanoylphorbol-13-acetate (TPA, 2 a) and to phorbol-12,13-didecanoate (PDD, 2 c) except that they possess no cyclopropane ring. Biological tests show that opening or complete removal of the cyclopropane ring leads to nearly total loss of irritant or tumorpromoting (tested in the case of 9 c and 10 c) activity. | | | |
Reference
| Z. Naturforsch. 35b, 1470—1475 (1980); eingegangen am 2. Juni 1980 | | | |
Published
| 1980 | | | |
Keywords
| Cocarcinogens, Phorbol, Structure-activity-relationship, Tumor Promoter, Irritants | | | |
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| default:Reihe_B/35/ZNB-1980-35b-1470.pdf | | | | Identifier
| ZNB-1980-35b-1470 | | | | Volume
| 35 | |
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