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1993 (1)
1Author    WendyK. Banham, JohnL., -.H., H. IllipRequires cookie*
 Title    N-Methylanilinocyanoacrylate Photosystem II Inhibitors. Structure-Activity Relationships  
 Abstract    Many 3-N-methylanilino cyanoacrylate derivatives are potent inhibitors o f photosynthetic electron transport at the PS II level in a thylakoid system isolated from Pisum sativum. These inhibitors are somewhat unusual in that they take more than 15 min to equilibrate with the binding site in contrast to most classical PS II inhibitors which tend to equilibrate rapidly i.e. within the mixing time o f seconds. The effects o f m ono-and disubstituents in the aryl nucleus on inhibitory activity were studied. The nature and position o f the substituent had no detectable influence on equilibration rate but a pronounced influence on inhibitory activity as measured by equilibrium p/ 50 values. Substituent position enhanced inhibitory activity in the order 3 ' > 2 ' » > 4 ' . As regards the nature o f the substituent, size appeared to be the most important parameter -the smaller the substituent the greater the activity. Such influences were in contrast to those in analogous 3-anilino-and 3-benzylamino-2-cyano-acrylate series where the com ­ parable order o f substituent position effect was 3' and 4' » 2 ' and where substituent hydro-phobicity rather than size was the most important factor. Disubstituted fluoro derivatives have given interesting insights into the preferred orientation o f these inhibitors at the binding site with the 2'-and 5'-positions interacting positively, the 4'-position, negatively, and the 3'-position neutrally. 
  Reference    Z. Naturforsch. 48c, 136 (1993); received December 3 1992 
  Published    1993 
  Keywords    Cyanoacrylates, Photosystem II Inhibitors, Structure Activity 
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 TEI-XML for    default:Reihe_C/48/ZNC-1993-48c-0136.pdf 
 Identifier    ZNC-1993-48c-0136 
 Volume    48