| | 1 | Author
| R. Tacke, A. Bentlage, W. S. Sheldrick, L. Ernst, K. Stoepel | Requires cookie* | | | Title
| Sila-Pharmaka, 24. Mitt. [1] Sila-Analoga von Nifedipin-ähnlichen 4-Aryl-2.6-cümethyl-1.4-dihydropyridin- 3.5-dicarbonsäure-dialkylestern, II Sila-Drugs, 24 th Communication [1] Sila-Analogues of Nifedipine-Like Di alkyl 4-Aryl-2,6-dimethyl-l,4-dihydropyridine- 3,5-dicarboxylates, II  | | | | Abstract
| In the course of systematic studies on sila-substituted drugs the nifedipine-like 1.4-di-hydropyridine derivatives 4 a, 4 b and 4 c were prepared and investigated with respect to sila-substitution effects. By X-ray diffraction analyses 4 a, 4 b and 4 c were found to be isostructural. The C/Si-analogues exhibit similar spasmolytic activities (in vitro, guinea pig ileum), comparable with that of nifedipine. However, the compounds differ sub-stantially in their in vivo activity, as measured by the antihypertensive effect on the renal-hypertensive rat. The experimental results are discussed with respect to the carbon/silicon exchange. | | | |
Reference
| Z. Naturforsch. 37b, 443—450 (1982); eingegangen am 25. September 1981 | | | |
Published
| 1982 | | | |
Keywords
| Sila-Analogues of Nifedipine Derivatives, X-ray, Pharmacological Activity, Structure-Activity Relationships | | | |
Similar Items
| Find | | | DEBUG INFO
| | | | | TEI-XML for
| default:Reihe_B/37/ZNB-1982-37b-0443.pdf | | | | Identifier
| ZNB-1982-37b-0443 | | | | Volume
| 37 | |
| 2 | Author
| Reinhold Tacke, Haryanto Linoh, MoayadT. Attar-Bashi, WilliamS. Sheldrick, Ludger Ernst, Roland Niedner, Joachim Frohnecke | Requires cookie* | | | Title
| Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III Sila-Pharmaca, 26th Communication [1] Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, III | | | | Abstract
| The potentially curare-hke silicon compounds 8a-Sf were synthesized and investigated with respect to their structure-activity relationships. The conformations of the com-pounds in the solid state and in solution were studied by X-ray diffraction analysis (8a-8e) and *H NMR spectroscopy (8a-8f), respectively. The muscle relaxing properties of 8a-8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 A model" for neuromuscular blocking agents. Einführung | | | |
Reference
| Z. Naturforsch. 37b, 1461—1471 (1982); eingegangen am 19. April 1982 | | | |
Published
| 1982 | | | |
Keywords
| Silicon Compounds, Curare-Like Activity, X-ray, Conformational Analyses, Structure-Activity Relationships | | | |
Similar Items
| Find | | | DEBUG INFO
| | | | | TEI-XML for
| default:Reihe_B/37/ZNB-1982-37b-1461.pdf | | | | Identifier
| ZNB-1982-37b-1461 | | | | Volume
| 37 | |
|
