Go toArchive
Browse byFacets
Bookbag ( 0 )
'Sponges' in keywords Facet   Publication Year 1993  [X]
Results  3 Items
Sorted by   
Publication Year
1Author    Francesco Cafieri, Ernesto Fattorusso, Yosef Mahajnah, Alfonso MangoniRequires cookie*
 Title    6-Bromo-5-hydroxy-3-indoIecarboxyaldehyde from the Caribbean sponge Oceanapia bartschi  
 Abstract    The organic extract from Oceanapia bartschi has been shown to contain the antibiotic di-terpene Ambliol A (1) and three indole derivatives, 3-bromoindole (2), 6-bromo-3-indole-carboxyaldehyde (3), and 6-bromo-5-hydroxy-3-indolecarboxyaldehyde (4). The structure of the novel compound 4 has been established from its spectroscopic ('H and 13C NMR, UV, IR, and MS) data. 
  Reference    Z. Naturforsch. 48b, 1408—1410 (1993); received March 291993 
  Published    1993 
  Keywords    Oceanapia bartschi, Oceanapid, Sponges, Indole Derivatives, Bromoindoles 
  Similar Items    Find
 TEI-XML for    default:Reihe_B/48/ZNB-1993-48b-1408.pdf 
 Identifier    ZNB-1993-48b-1408 
 Volume    48 
2Author    R. A. Ta N, T. Eeyapant3, PatriciaK. Reis3, V. Ictor, W. Rayb, LudgerW. Ittec, Peter Proksch3Requires cookie*
 Title    Brominated Secondary Compounds from the Marine Sponge Verongia aerophoba and the Sponge Feeding Gastropod Tylodina perversa  
 Abstract    Analysis of the marine sponge Verongia aerophoba from the Canary islands afforded the brominated secondary constituents isofistularin-3, aerophobin-1 and aerophobin-2 which are probably involved in the chemical defense of the sponge. In addition the yellow pigment urani-dine and the unusual sterol aplysterol were isolated. The patterns o f brominated compounds were almost superimposable when samples of V. aerophoba from different islands were com­ pared by HPLC indicating de novo synthesis by the sponge or by endosymbiotic microorgan­ isms rather than uptake by filter feeding. The only differences observed between the different samples analyzed were with regard to the total concentrations of brominated compounds which varied from 7.2-12.3% of the dry weight dependent on the different collection sites. The Opisthobranch gastropod Tylodina perversa is specialized for feeding on V. aerophoba. Chemical analysis of the gastropod revealed the sponge constituents uranidine, isofistularin-3, aerophobin-1 and aerophobin-2 as well as aerothionin, a further brominated compound which is apparently a biotransform ation product of the brom inated sponge constiiuents. 
  Reference    Z. Naturforsch. 48c, 640—644 (1993); received March 17 1993 
  Published    1993 
  Keywords    Verongia aerophoba, Tylodina perversa, Sponges, G astropods, Secondary Compounds 
  Similar Items    Find
 TEI-XML for    default:Reihe_C/48/ZNC-1993-48c-0640.pdf 
 Identifier    ZNC-1993-48c-0640 
 Volume    48 
3Author    R. Teeyapant3, H.J W Oerdenbagb, P. Kreis3, J. Hacker0, V. W. Rayd, L. Witte6, P. Proksch3Requires cookie*
 Title    Antibiotic and Cytotoxic Activity of Brominated Compounds from the Marine Sponge Verongia aerophoba  
 Abstract    Analysis of the marine sponge Verongia aerophoba from the Canary Islands afforded eight brominated secondary metabolites including the small molecular weight compounds aeroply-sinin-1 (5) and the dienone (7) which were previously shown to arise by enzymatically cata­ lyzed degradation of aerophobin-2 (4) and isofistularin-3 (1) following breakdown of the cellu­ lar compartmentation o f the sponge. All compounds were identified from their NM R and mass spectra. Aeroplysinin-1 as well as dienone which arise from isofistularin-3 or aeropho­ bin-2 by biotransformation within the sponge showed a significantly higher antibiotic as well as cytotoxic activity than their biogenetic precursors. Antibiotic activity was studied with re­ spect to several gram-positive and gram-negative bacteria including B. subtilis, S. aureus and E. coli. The MICs (MBCs) of aeroplysinin-1 (5) and the dienone (7) varied between 12.5-25 (50-100) ng/ml respectively. Cytotoxicity was tested in vitro towards HeLa cells, a human cervix uteri tumour cell line. Aeroplysinin-1 (5) and the dienone (7) displayed pronounced cytotoxic activity with IC50s of 3.0 and 3.2 |iM respectively. A five-fold increase in cytotoxicity was observed after O-acetylation of the dienone (7). The IC50 of the dienone O-acetate (0.6 ^im) was comparable to that o f the clinically used anticancer drug cisplatin (0.7 ^m). 
  Reference    Z. Naturforsch. 48c, 939—945 (1993); received July 16/August30 1993 
  Published    1993 
  Keywords    Verongia aerophoba, Sponges, Secondary Metabolites, Structure Elucidation, Antibiotic Activity 
  Similar Items    Find
 TEI-XML for    default:Reihe_C/48/ZNC-1993-48c-0939.pdf 
 Identifier    ZNC-1993-48c-0939 
 Volume    48