| | 1 | Author
| Martin Jäger1, Paul Schuler1, HartmutB. Stegmann, Antal Rockenbauerb | Requires cookie* | | | Title
| Molecular Recognition Analyzed by Observing Intramolecular Interconversion with E PR Spectroscopy  | | | | Abstract
| Molecular recognition between Rebek's cleft R and 4-(2-benzimidazolyl)-aminomethyl-2,6-di-rm-butyl-phenol (Bi) is investigated by means of EPR spectroscopy. Their specific inter-molecular interactions are distinguished from non-specific interactions represented by mere protonation on addition of benzoic acid. Both interactions are related to intramolecular in terconversions at the CQ-atom of Bi*, where a two-jump mechanism is found for free and protonated Bi* and a two-site exchange for the complexed ligand. While NMR spectroscopy indicates the existence of 1:1 and 1:2 receptor-substrate complexes, the faster time scale of EPR spectroscopy allows to identify one 1 : 2 as well as three 1 : 1 associates and to elucidate their formation conditions. Based upon the corresponding hf parameters, binding modes and sites are proposed for the key-in-the-lock system. | | | |
Reference
| Z. Naturforsch. 53b, 1511—1519 (1998); received July 22 1998 | | | |
Published
| 1998 | | | |
Keywords
| Rock-Key-Equilibria, Spin Labeling, Molecular Dynamics | | | |
Similar Items
| Find | | | DEBUG INFO
| | | | | TEI-XML for
| default:Reihe_B/53/ZNB-1998-53b-1511.pdf | | | | Identifier
| ZNB-1998-53b-1511 | | | | Volume
| 53 | |
|
