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'Spin Labeling' in keywords Facet   section ZfN Section C  [X]
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1990 (1)
1987 (1)
1Author    S. Mazzuca, L. SportelliRequires cookie*
 Title    Thermal Behaviour of Lymphocyte Membrane: ESR Investigation  
 Abstract    The order parameter, S, of the plasma membrane of in toto human peripheral blood lym­ phocytes was obtained by electron spin resonance spectroscopy in the temperature range 25-41 C. This membrane is completely in the liquid crystalline state above 31 C. In presence of the antigen ETB from Staphylococcus aureus at the concentration of 4 (ig/3 * 107 cells an overall decrease of the order parameter for this membrane is observed. The decrease of 5 is followed by an upwards shift at about 35 C of the temperature of the liquid crystalline state. 
  Reference    Z. Naturforsch. 45c, 1060—1062 (1990); received April 6 1990 
  Published    1990 
  Keywords    Plasma Membrane, Lymphocyte, Phase Transition, Staphylococcal Enterotoxin B, Spin Labeling 
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 TEI-XML for    default:Reihe_C/45/ZNC-1990-45c-1060.pdf 
 Identifier    ZNC-1990-45c-1060 
 Volume    45 
2Author    G. Eo Rg, S. Osnovsky, ShuW. En, Li, M. Ahesw, AraR. AoRequires cookie*
 Title    In the Search for New Anticancer Drugs, XXI. Spin Labeled Nitrosoureas  
 Abstract    The spin labeled nitrosoureas 7 a—e and 12 were synthesized and evaluated in vivo for their anticancer activities against the murine lymphocytic leukem ia P388. C om pounds 7 a —c, 7 e and 12 possessed activities ranging from 31 to 542 percent increase in life span (% IL S), w hereas com ­ pound 7 d was marginal (% IL S = 21). All CD2Fj male mice treated with the most active com ­ pounds (7a and 12) at 35 mg/kg for 9 days were alive after 30 days, w hereas all mice treated with the clinical drug CCNU (lc) succumbed. Compounds 7 a —e and 12 were further evalu­ ated for their antineoplastic activity against lymphoid leukem ia L1210. C om pounds 7a and 12 exhibited, on day 60, a % ILS of 713 and 620, respectively. The lipophilicities of com pounds 7 a —e and 12 were determ ined using the E PR and UV methods. Compounds 7a and 12 which differ from CCNU and M eCCNU by the replacement of the cyclohexyl and methylcyclohexyl groups with six and five m em bered nitroxyl radical moieties were more hydrophilic than the clinical drugs. 
  Reference    Z. Naturforsch. 42c, 921—931 (1987); received August 14 1986 
  Published    1987 
  Keywords    Nitrosoureas, Nitroxyl Radicals, Spin Labeling, Anticancer Drugs, Leukemia P388 and L1210 
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 TEI-XML for    default:Reihe_C/42/ZNC-1987-42c-0921.pdf 
 Identifier    ZNC-1987-42c-0921 
 Volume    42