| | 1 | Author
| G. Eo Rg, S. Osnovsky, ShuW. En, Li, M. Ahesw, AraR. Ao | Requires cookie* | | | Title
| In the Search for New Anticancer Drugs, XXI. Spin Labeled Nitrosoureas  | | | | Abstract
| The spin labeled nitrosoureas 7 a—e and 12 were synthesized and evaluated in vivo for their anticancer activities against the murine lymphocytic leukem ia P388. C om pounds 7 a —c, 7 e and 12 possessed activities ranging from 31 to 542 percent increase in life span (% IL S), w hereas com pound 7 d was marginal (% IL S = 21). All CD2Fj male mice treated with the most active com pounds (7a and 12) at 35 mg/kg for 9 days were alive after 30 days, w hereas all mice treated with the clinical drug CCNU (lc) succumbed. Compounds 7 a —e and 12 were further evalu ated for their antineoplastic activity against lymphoid leukem ia L1210. C om pounds 7a and 12 exhibited, on day 60, a % ILS of 713 and 620, respectively. The lipophilicities of com pounds 7 a —e and 12 were determ ined using the E PR and UV methods. Compounds 7a and 12 which differ from CCNU and M eCCNU by the replacement of the cyclohexyl and methylcyclohexyl groups with six and five m em bered nitroxyl radical moieties were more hydrophilic than the clinical drugs. | | | |
Reference
| Z. Naturforsch. 42c, 921—931 (1987); received August 14 1986 | | | |
Published
| 1987 | | | |
Keywords
| Nitrosoureas, Nitroxyl Radicals, Spin Labeling, Anticancer Drugs, Leukemia P388 and L1210 | | | |
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| default:Reihe_C/42/ZNC-1987-42c-0921.pdf | | | | Identifier
| ZNC-1987-42c-0921 | | | | Volume
| 42 | |
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