| | 1 | Author
| Wolfgang Lohmann, KlausG. Bensch, Jörg Schreiber, Elisabeth Müller, Konrad Schwemmle, Herbert Feustel, Rolf-Dieter Filler | Requires cookie* | | | Title
| Paramagnetic Changes in Pulmonary Tumors  | | | | Abstract
| Electron spin resonance studies on healthy and tum erous hum an lung samples have been con ducted in order to determ ine possible differences in free radical concentration and shape o f the spectra between the different sections o f the lung. It could be shown that in healthy lung tissue the signal caused by the sem idehydroascorbate (SDA) radical is not prom inent because o f the prevailing high partial oxygen pressure. On form ation o f a tumor, the spin concentration increases, possibly due to the higher metabolic rate; here, the SDA peak is also more pronounced which indicates alterations in the interaction between cell constituents and ascorbic acid. W ithin the tum or, the spin concentration is considerably reduced which is probably caused by a still higher concentration o f ascorbic acid. A ddition o f ascorbic acid to the different lung specimens enhanced the just described effect while oxidizing substances, such as H 2Oa, reversed it. | | | |
Reference
| Z. Naturforsch. 36c, 5—8 (1981); received Septem ber 9/O ctober 20 1980 | | | |
Published
| 1981 | | | |
Keywords
| ESR, Pulmonary Tumors, Ascorbic Acid, Spin Concentration | | | |
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| | | | | TEI-XML for
| default:Reihe_C/36/ZNC-1981-36c-0005.pdf | | | | Identifier
| ZNC-1981-36c-0005 | | | | Volume
| 36 | |
| 2 | Author
| Wolfgang Lohmann | Requires cookie* | | | Title
| On a Possible Mechanism of Action of Interferon | | | | Abstract
| The effect o f interferon on the ESR spectra o f erythrocytes treated with ascorbic acid has been investigated. This model system has been chosen since it represents identically the spectra obtained in cases with acute lymphatic leukemia. The data obtained show that small interferon concentrations increase, while larger concentrations decrease the effect produced by ascorbic acid resulting, finally, in the original erythrocyte ESR spectrum. Atomic absorption studies reveal the presence of copper which might be part of the active principle. | | | |
Reference
| Z. Naturforsch. 36c, 323—325 (1981); received November 18 1980 | | | |
Published
| 1981 | | | |
Keywords
| Interferon, Cancer, Ascorbic Acid, Spin Concentration, Electron Spin Resonance Spectrum | | | |
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| | | | | TEI-XML for
| default:Reihe_C/36/ZNC-1981-36c-0323.pdf | | | | Identifier
| ZNC-1981-36c-0323 | | | | Volume
| 36 | |
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