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1995 (1)
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1Author    Bai Zhu, G.Wilse RobinsonRequires cookie*
 Title    Sheng  
 Abstract    The structure and properties of a 1.791 molal aqueous LiF solution is investigated by performing molecular dynamics simulations using a water model with both bond flexibility and instantaneously responsive polarization. On average, each cation is in close contact with about one anion. This causes a strong overlap of the hydration shells and an almost complete breakdown of the surround­ ing water structure. While the lone pairs of the hydration waters in the first Li+ shell occupy preferentially tetrahedral positions, the orientational distribution of the solvent molecules around F~ is quite uniform. By comparing various autocorrelation functions of water molecules in the solution and in the pure liquid, the influence of solvated ions on the translational, rotational and vibrational motions of hydration water can be studied. M o le c u la r D y n a m ic s S tu d y o f a n A q u e o u s L iF S o lu tio n 
  Reference    Z. Naturforsch. 46a, 221—228 (1991); received October 4 1990 
  Published    1991 
  Keywords    Hydration, Ions, Water, Solubility, Ion-pairs 
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 TEI-XML for    default:Reihe_A/46/ZNA-1991-46a-0221.pdf 
 Identifier    ZNA-1991-46a-0221 
 Volume    46 
2Author    Heinz Gamsjäger1, Harald Marhold1, Erich Königsberger1, YiJung Tsai1, Hans Kolmer2Requires cookie*
 Title    S o lid - 3) 4 * **H20  
 Abstract    S o lu te P h a s e E q u ilib ria in A q u e o u s S o lu tio n s IX . T h e rm o d y n a m ic A n a ly s is o f S o lu b ility M e a s u r e m e n ts : L a (0 H) M(C 0 Dedicated to Prof. Hitoshi Ohtaki on the occasion of his 60th birthday The aqueous solubilities of La(OH)p^(COaJjA 0.1 H20, basic lanthanum carbonate of ancylite type, have been investigated as a function of ionic strength at 25.0 °C. The stoichiometric solubility constants defined by log* K1 0 = log [La3 + ] + 1.1 log pco — 3 log [H+1 have the values 11.10, 11.32, 11.42, 11.63, and 11.70 for / = 0.1, 0.25, 1.0, 2.0, and 4.0 mol kg (Na)C104 respectively. The extrapolation to infinite dilution using the Pitzer equations resulted in a "thermodynamic" solubility constant, log* K° 0 = 10.48 ± 0.08. This in turn led to the Gibbs energy of ancylite formation: Af G f98 {La(OH)08(CO3)11 0.1 H20} = -1.531.5 kJ mol-1. 
  Reference    Z. Naturforsch. 50a, 59—64 (1995); received October 1 1994 
  Published    1995 
  Keywords    Solubility, Carbonates, Lanthanum, Thermodynamics, Pitzer model 
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 TEI-XML for    default:Reihe_A/50/ZNA-1995-50a-0059.pdf 
 Identifier    ZNA-1995-50a-0059 
 Volume    50 
3Author    F.C M Dnessens, R.M H VerbeeckRequires cookie*
 Title    Evidence for Intermediate Metastable States during Equilibration of Bone and Dental Tissues  
 Abstract    Experimental data were collected on the solubility equilibrium of the mineral of bone, tooth enamel and calcium phosphate renal stones. Evaluation in the form of potential diagrams of Ca(OH) 2 versus H3P 0 4 shows that Ca/P ratios of 1, 4/3, 10/7, 3/2 and 5/3, related to phases like brushite, octocalcium phosphate, whitlockite, defective apatite and hydroxyapatite respectively can be important. These facts allow the interpretation that many of these calcium phosphates are present simultaneously in biominerals or that they are formed during the equilibration. 
  Reference    Z. Naturforsch. 35c, 262 (1980); received December 27 1979 
  Published    1980 
  Keywords    Calcium Phosphates, Solubility, Bone, Dental Enamel 
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 TEI-XML for    default:Reihe_C/35/ZNC-1980-35c-0262.pdf 
 Identifier    ZNC-1980-35c-0262 
 Volume    35 
4Author    Anders Ljungqvista, Dong-M Ei Feng3, Cyril Bowers, WilliamA H Ookc, Karl Folkers3Requires cookie*
 Title    Design, Synthesis and Biological Evaluation of Antagonists of LHRH by Criteria of Potency, Safety and Solubility  
 Abstract    Some analogs o f Antide and congeners with higher water solubility have been synthesized by substitutions in positions 1, 5 or 6 with hydrophilic residues. In position 1, D -3 -Q a l has been incorporated in four peptides and D -3 -P a l in one peptide. In positions 5 and 6, D and L -3 -P a l, PzAla and (DSer)Lys have been tried. In one peptide, D -(A cD S er)L y s was substi­ tuted in position 6. M ost o f the new analogs had lower AOA (antiovulatory activity) than the parent com ­ pounds but three potent analogs were identified. The first one, [N -A c -D -3 -Q a l',D p C lP h e 2,D -3 -P a l3,c-PzA C A la5,D -P ic L y s 6,ILys8,D -A l a l0]-L H R H , had 55% A O A at 0.25 ng and 100% at 0.5 /ug. Its E D 50 for in vitro histamine release was 171 ± 17 ^g/m l which is an increase from 4 9 ± 4 .8 >ug/ml for the parent com pound with N -A c -D -2 -N a l [1], The second analog, [N -A c -D -2 -N a l',D p C lP h e 2,D -3 -P a l3,PicLys5,D -(D S e r)L y s6,ILys8,D -A l a 10]-L H R H , had 69% A OA at 0.25 /ug and 95% at 0.5 fig. This analog released somewhat more histamine than the parent analog featuring D -P ic L y s6, the E D S0 being 18 //g/m l compared to 93 ± 11 for the parent analog. The third analog is: [ N -A c -D -2 -N a t 1, D pClPhe2,D -3 -P a l3,c-PzA C A la5,D -P z A la 6,ILys8,D A la ']-L H R H . The AOA for this analog was 63% at 0.25 //g and the E D 50 for histamine release 8 8 ± 6 .4 ^g/ml. histamine from mast cells [1], These features in­ clude a group of hydrophobic amino acids at the N-terminal and strongly basic residues in positions 6 and 8 , notably D -Arg6,Arg8. A prime example o f this class o f antagonists is [N -A c -D -2 -N a l',D -4 F -P h e 2 ,D -T rp 3, D -A rg 6] -LH R H [2], It was recently shown that some antag­ onists bind to rat peritoneal mast cells and mem­ brane preparations and that the binding was relat­ ed to the release of histamine [3]. We recently developed Antide (analog 1, Table III) which lacked strongly basic residues and which showed high potency and negligible histamine re­ lease [4], F urther evaluation of the anaphylactoid activity o f Antide concluded that Antide "repre­ sents a new generation of LH R H antagonists with an improved safety m argin" [5]. Prolonged duration of inhibition of gonado­ tropin secretion in overectomized monkeys using single [6 ] or multiple [7] doses of Antide has also been established. The same group observed a long-term supres-sion o f testosterone secretion in male monkeys after a single dose of Antide [8 ]. 
  Reference    Z. Naturforsch. 46b, 1231 (1991); received March 1 1991 
  Published    1991 
  Keywords    LH R H -A ntagonists, Antiovulatory Activity, Histam ine Release, Solubility 
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 TEI-XML for    default:Reihe_B/46/ZNB-1991-46b-1231.pdf 
 Identifier    ZNB-1991-46b-1231 
 Volume    46