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1981 (1)
1980 (1)
1Author    Georg Rampold, Elsa Lundanes, Karl Folkers, Wolfgang Voelter, Hubert Kalbacher+, Emile BliznakovRequires cookie*
 Title    Solid Phase Synthesis of Thymopoietin-(32-36) Using Adpoc Amino Acids and its Biological Activity +  
 Abstract    An exemplary peptide has been synthesized for the first time by an automated solid-phase instrumentation which utilized the new Adpoc (1 -(1-adamantyl) -1 -methylethoxycarbonyl-) group for protection of the a-amino groups of the amino acids. The pentapeptide, thymo-poietin-(32-36) was synthesized, and shown to be pure by criteria including HPLC. Using a Cytoxan (cyclophosphamide) model system for suppression of a primary, hemolytic, humoral, antibody level, thymopoietin-(32-36) showed low activity, and reversed the suppressing effect of Cytoxan. This biological activity apparently is the result of cum-mulative effect. 
  Reference    Z. Naturforsch. 35b, 1476—1478 (1980); received May 27 1980 
  Published    1980 
  Keywords    Adpoc Amino Acids, Solid Phase Synthesis, Thymopoietin-(32-36) 
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 TEI-XML for    default:Reihe_B/35/ZNB-1980-35b-1476.pdf 
 Identifier    ZNB-1980-35b-1476 
 Volume    35 
2Author    Kosaku Nöda, Erhard GrossRequires cookie*
 Title    Solid-Phase Synthesis of Peptides via a,ß-Unsaturated Amino Acids. Incorporation of the Amide Gronp in encZo-Positions  
 Abstract    Dehydroalanine is introduced as pseudo-protecting group for the to-amide function of Asn and Gin in solid-phase peptide synthesis. Using Boc-X(Dha-NHMe)-OH (X = Asp or Glu), the model peptides, L-Leu-L-Asn-Gly-NH2 and L-Leu-Lr-Gln-Gly-NH2, were synthesized. 
  Reference    Z. Naturforsch. 36b, 1345—1347 (1981); received July 15 1981 
  Published    1981 
  Keywords    Amide Group, Dehydroalanine, Peptide, Solid-Phase Synthesis 
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 TEI-XML for    default:Reihe_B/36/ZNB-1981-36b-1345.pdf 
 Identifier    ZNB-1981-36b-1345 
 Volume    36