| | 2 | Author
| Joachim Granzin, W. Olfram Saenger, Ryszard Stolarski, David Shugar | Requires cookie* | | | Title
| Solid State and Solution Structures of an Adenine Analogue of the Antiviral Acyclonucleoside 9-(l,3-Dihydroxy-2-propoxymethyl)guanine  | | | | Abstract
| The title com pound, 9-(l,3-dihydroxy-2-propoxym ethyl)adenine (D H P-A de), an analogue o f the antiviral acyclonucleoside 9-(l,3-dihydroxy-2-propoxym ethyl)guanine (D H P G), crys tallizes in the m onoclinic space group P 2,, with unit cell dimensions o f a = 10.848(4), b = 8.765(3), c = 11.432(4) A, ß = 102.14(3)°, with two independent molecules in the asymmetric unit. The crystal structure o f D H P-A de was determined and compared with that for D H PG . The solution conform ations o f both acyclonucleosides were also determined with the aid o f 'H and 13C N M R spectroscopy. In the solid state the acyclic chain may adopt a "folded" form, i.e. gauche about the C (l) —O (l') bond (as in D H P-A de), or an "extended" form (as in D H PG), results which corre spond to the rotations about this bond in solution. A general discussion is presented o f the conform ations o f the acyclic chains o f various acyclonucleosides, from the antiviral 9-(2-hydroxyethoxymethyl)guanine (Acyclovir, ACV) through to 2',3'-^co-nucleosides, both in the solid state and in solution, and the relevance o f these to biological activities. | | | |
Reference
| Z. Naturforsch. 45c, 915 (1990); received December 21 1989/April 27 1990 | | | |
Published
| 1990 | | | |
Keywords
| Antiviral Acyclonucleoside, Solid State, Solution Structures | | | |
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| default:Reihe_C/45/ZNC-1990-45c-0915.pdf | | | | Identifier
| ZNC-1990-45c-0915 | | | | Volume
| 45 | |
| 3 | Author
| M. Veith | Requires cookie* | | | Title
| Cyclische Diazastannylene, II 1 Intermolekulare Lewis-Säure-Base-Addukte bei 1.3.2.4A 2 -Diazasilastannetidinen Cyclic Diazastannylenes, II 1 Intermolecular Lewis-Acid-Base Adducts of 1, 3,2,4A 2 -Diazasilastannetidines | | | | Abstract
| -diazasilastannetidines can be prepared as mono-mers (organyl = <erf-butyl) or dimers (organyl = isopropyl) in nonpolar solvents, depending on the organic nitrogen substituent. The formation of the dimer, which is due to an intermolecular Lewis-acid-base interaction of Sn(II) with nitrogen, can be initiated by solidification. When the tertf-butyl compound is cooled below 0 °C two crystalline modi-fications are found: a monoclinic phase (C 2/c; a= 10.655(5); b = 24.75(1); c = 17.334(9) Ä; ß = 106.9(1)°) and a triclinic phase (P I; a = 10.68(1); b = 13.51(1); c = 12.36(1) A; a = 96.2(1); ß = 102.6(1); y = 118.4(1)°). The crystal structures turn out to be built of dimeric and monomeric units in the first case and presumably only dimeric species in the second case. The isopropyl derivative crystallizes in the space group P 2i/b (a = 10.77(1); b= 12.14(2); c = 11.15(2) A; ß = 120.2(2)°) with only dimeric units being present, as in the liquid. Interrelationships between the three structures are discussed. | | | |
Reference
| (Z. Naturforsch. 33b, 1—6 [1978]; eingegangen am 5. September/6. Oktober 1977) | | | |
Published
| 1978 | | | |
Keywords
| Diazastannylenes, Solid State, X-ray, Crystal Structure, NMR l, 3-Diorganyl-2, 2-dimethyl-I, 3, 2, 4A 2 | | | |
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| default:Reihe_B/33/ZNB-1978-33b-0001.pdf | | | | Identifier
| ZNB-1978-33b-0001 | | | | Volume
| 33 | |
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