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'Solid Phase Peptide Synthesis' in keywords
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1997 (1)
1995 (1)
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1981 (1)
1Author    Reza Arshady, Ivar UgiRequires cookie*
 Title    Solid Phase Peptide Synthesis by Four Component Condensation: Peptide Formation on an Isocyano Polymer Support  
 Abstract    Coupling of various protected amino acids or small peptides on an isocyano polymer and in the presence of 1 -methyl-3-formylindole dem-onstrates the feasibility of peptide formation by four component condensation on a polymer support, and the final peptide is detached from the resin by 50% trifluoroacetic acid in aceto-nitrile at room temperatme. 
  Reference    Z. Naturforsch. 36b, 1202—1203 (1981); received May 4 1981 
  Published    1981 
  Keywords    Solid Phase Peptide Synthesis, Four Component Condensation, Isocyano Polymer Support, Anchoring Technique 
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 TEI-XML for    default:Reihe_B/36/ZNB-1981-36b-1202_n.pdf 
 Identifier    ZNB-1981-36b-1202_n 
 Volume    36 
2Author    Prof Dr, ErnstRequires cookie*
 Title    Zur Festphasenpeptidsynthese des Makrophagen-migrationsinhibierenden Faktors der Maus (mMIF): Ein Vergleich verschiedener Syntheseansätze zur Darstellung der schwierigen C-terminalen Sequenz mMIF(93-115)  
 Abstract    Solid Phase Peptide Synthetic A ppro ach es to M ouse M acrophage M igration Inhibitory Factor (m M IF): C om parison of D ifferent Strategies Producing the C-Terminal D ifficult Sequence P eptide m M IF (9 3 -1 1 5) Thom as Kaiser, W olfgang V oelter* From solid phase peptide synthetic approaches of mMIF(93-115) the C-terminal sequence turned out to be a typical "difficult sequence" peptide. Various stepwise syntheses were performed with different resins and coupling reagents. The Peptide was synthesized in 90% yield by solid phase fragment condensation of protected mMIF(93-108) to mMIF(109-115) '2-Chlorotrityl' resin bound. 
  Reference    Z. Naturforsch. 52b, 281—295 (1997); eingegangen am 4. Dezember 1996 MIF 
  Published    1997 
  Keywords    Solid Phase Peptide Synthesis, Difficult Sequence, Fragment Condensation, Coupling Conditions 
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 TEI-XML for    default:Reihe_B/52/ZNB-1997-52b-0281.pdf 
 Identifier    ZNB-1997-52b-0281 
 Volume    52 
3Author    Karl Eisele, Fernando Dias Costa, Carlos Pascual, BeatusO. Fenloch-HähnleRequires cookie*
 Title    A Simple Method to Prepare Affinity Resins on Cellulose Basis  
 Abstract    Affinity resins with different spacer arms were synthesized analogues to the solid phase peptide synthesis using aminoethyl cellulose or carboxym ethyl cellulose as matrix. The spacer arms could be varied in length and rigidity. Especially spacer arms consisting o f poly am ino acids can be synthesized with a defined amount o f am ino acid residues specifically in the low molecular weight ranges. The method is also applicable to other matrices w hich are not susceptible to 1 N HC1 in glacial acetic acid, trethylamine, m ethylene chloride and dim ethylform am ide. The synthesis o f affinity resins with different spacer arms for the purification o f androgen receptors is described as an exam ple o f the method. 
  Reference    Z. Naturforsch. 39c, 1048—1051 (1984); received August 8 1984 
  Published    1984 
  Keywords    Affinity Resins, Solid Phase Peptide Synthesis, C ellulose, Androgen Receptor 
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 TEI-XML for    default:Reihe_C/39/ZNC-1984-39c-1048.pdf 
 Identifier    ZNC-1984-39c-1048 
 Volume    39 
4Author    Anna Janecka3, StevenK. Oerberb, Tomasz Janecki3, Cyril Bowersc, Karl Folkers3Requires cookie*
 Title    N5-PyrazinylcarbonyIornithine, an Effective Substituent for Position 5 of Antagonists of LHRH  
 Abstract    Com puter modeling was used to find an effective substituent for position 5 in antagonists of the luteinizing hormone-releasing hormone (LHRH). In particular, it was desired to replace ds-3-(4-pyrazinylcarbonylaminocyclohexyl)alanine in position 5 because this sub­ stituent is laborious to synthesize. Calculations revealed that N5-pyrazinylcarbonylornithine (PzOrn) should be a suitable substitute for cPzACAla, with N6-pyrazinylcarbonyllysine (PzLys) being a second choice. Twelve analogs were synthesized in four series with DNal or DQal in position 1 and ILys or Arg in position 8. Biological assays validated the calculations and show that antagonists with PzOrn are more potent in antiovulatory assay than antag­ onists with PzLys. The antagonists with PzOrn were comparable in AOA with antagonists with cPzACAla. What is also im portant, antagonists with PzOrn released significantly less histamine than those with cPzACAla. 
  Reference    Z. Naturforsch. 50b, 147—150 (1995); received April 27 1994 
  Published    1995 
  Keywords    LH RH Antagonists, Com puter Modeling, Antiovulatory Activity, Histamine Release, Solid Phase Peptide Synthesis 
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 TEI-XML for    default:Reihe_B/50/ZNB-1995-50b-0147.pdf 
 Identifier    ZNB-1995-50b-0147 
 Volume    50