| 3 | Author
| Karl Eisele, Fernando Dias Costa, Carlos Pascual, BeatusO. Fenloch-Hähnle | Requires cookie* | | Title
| A Simple Method to Prepare Affinity Resins on Cellulose Basis  | | | Abstract
| Affinity resins with different spacer arms were synthesized analogues to the solid phase peptide synthesis using aminoethyl cellulose or carboxym ethyl cellulose as matrix. The spacer arms could be varied in length and rigidity. Especially spacer arms consisting o f poly am ino acids can be synthesized with a defined amount o f am ino acid residues specifically in the low molecular weight ranges. The method is also applicable to other matrices w hich are not susceptible to 1 N HC1 in glacial acetic acid, trethylamine, m ethylene chloride and dim ethylform am ide. The synthesis o f affinity resins with different spacer arms for the purification o f androgen receptors is described as an exam ple o f the method. | | |
Reference
| Z. Naturforsch. 39c, 1048—1051 (1984); received August 8 1984 | | |
Published
| 1984 | | |
Keywords
| Affinity Resins, Solid Phase Peptide Synthesis, C ellulose, Androgen Receptor | | |
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| default:Reihe_C/39/ZNC-1984-39c-1048.pdf | | | Identifier
| ZNC-1984-39c-1048 | | | Volume
| 39 | |
4 | Author
| Anna Janecka3, StevenK. Oerberb, Tomasz Janecki3, Cyril Bowersc, Karl Folkers3 | Requires cookie* | | Title
| N5-PyrazinylcarbonyIornithine, an Effective Substituent for Position 5 of Antagonists of LHRH  | | | Abstract
| Com puter modeling was used to find an effective substituent for position 5 in antagonists of the luteinizing hormone-releasing hormone (LHRH). In particular, it was desired to replace ds-3-(4-pyrazinylcarbonylaminocyclohexyl)alanine in position 5 because this sub stituent is laborious to synthesize. Calculations revealed that N5-pyrazinylcarbonylornithine (PzOrn) should be a suitable substitute for cPzACAla, with N6-pyrazinylcarbonyllysine (PzLys) being a second choice. Twelve analogs were synthesized in four series with DNal or DQal in position 1 and ILys or Arg in position 8. Biological assays validated the calculations and show that antagonists with PzOrn are more potent in antiovulatory assay than antag onists with PzLys. The antagonists with PzOrn were comparable in AOA with antagonists with cPzACAla. What is also im portant, antagonists with PzOrn released significantly less histamine than those with cPzACAla. | | |
Reference
| Z. Naturforsch. 50b, 147—150 (1995); received April 27 1994 | | |
Published
| 1995 | | |
Keywords
| LH RH Antagonists, Com puter Modeling, Antiovulatory Activity, Histamine Release, Solid Phase Peptide Synthesis | | |
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| default:Reihe_B/50/ZNB-1995-50b-0147.pdf | | | Identifier
| ZNB-1995-50b-0147 | | | Volume
| 50 | |
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