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'Silybin' in keywords
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1984 (1)
1983 (1)
1Author    The Stereochemistry, F. Silybin, Hermann Lotter, H. Ildebert, W. AgnerRequires cookie*
 Title    Zur Stereochemie von Silybin  
 Abstract    The X-ray Structure of Silybin from Silybum marianum G aertn. was determined. The com ­ pound was found to be a diastereom eric m ixture (1 : 1) in the benzodioxane part of the molecule explaining several tentative aspects about the structure known from NM R-m easurem ents and HPLC-separations. Einführung 
  Reference    Z. Naturforsch. 38c, 339—341 (1983); received February 22 1983 
  Published    1983 
  Keywords    Silybin, Silybum marianum, X-Ray Structure, Absolute Configuration 
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 TEI-XML for    default:Reihe_C/38/ZNC-1983-38c-0339.pdf 
 Identifier    ZNC-1983-38c-0339 
 Volume    38 
2Author    HermannL. LotterRequires cookie*
 Title    Untersuchung der Struktur-Wirkungsbeziehung antihepatotoxischer Naturstoffe (Silybin-Antamanid) durch Röntgenstrukturanalyse  
 Abstract    Both, the flavonolignane silybin and the decapeptide antam anide, protect anim als against the mushroom poison phalloidin from Amanita species. The X-ray structures o f silybin and anta­ manide have been solved in previous studies. Here an attempt has been m ade to explain the antagonistic antihepatotoxic protection by sim ilar chem ical structure elem ents in the two compounds. It can be shown that two aromatic rings in a definite arrangement are essential for the attachment to the target structure o f the liver cell membrane. Com parable pharm acological tests are discussed. 
  Reference    Z. Naturforsch. 39c, 535 (1984); received Decem ber 2 1983/March 26 1984 
  Published    1984 
  Keywords    Silybin, Antamanide, Phalloidin, Structure Activity Relationship, A ntihepatotoxic Principle 
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 TEI-XML for    default:Reihe_C/39/ZNC-1984-39c-0535.pdf 
 Identifier    ZNC-1984-39c-0535 
 Volume    39