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1986 (1)
1983 (1)
1Author    Reinhold Tacke3, A. Nke Bentlage-Felten, H. Aryanto, Linoha, StephenM. AgdabRequires cookie*
 Title    Sila-Pharmaka, 34. Mitt. [1] Sila-Analoga des Triparanols und Ethamoxytriphetols: Synthese sowie pharmakologische und toxikologische Eigenschaften  
 Abstract    Starting from tetram ethoxysilane, sila-triparanol 4b and sila-ethamoxytriphetol 8b were synthesized by four-step syntheses. 4b and 8b exhibit a strong hypolipidem ic activity in mice after p.o. administration. W hereas 4b and its carbon analogue triparanol (4a) show a similar hypolipidem ic potency, 8b was found to be less potent than its carbon analogue etham oxy­ triphetol (8a). The silicon com pounds 4b and 8b are less toxic (repeated administration over a period o f 8 days) than the corresponding carbon analogues 4a and 8a, respectively. 
  Reference    Z. Naturforsch. 41b, 649 (1986); eingegangen am 11. Novem ber 1985 
  Published    1986 
  Keywords    Sila-Substitution, Triparanol, Etham oxytriphetol, H ypolipidem ic Activity Toxicological Properties 
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 TEI-XML for    default:Reihe_B/41/ZNB-1986-41b-0649.pdf 
 Identifier    ZNB-1986-41b-0649 
 Volume    41 
2Author    Reinhold Tacke, Hartwig Lange, WilliamS. Sheldrick, Günter Lambrecht, Ulrich Moser, Ernst MutschierRequires cookie*
 Title    Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon Sila-Pharmaca, 31 th Communication [1J Synthesis, Structure, and Pharmacological Properties of Diphenyl(2-piperidinoethoxymethyl)silanol and its Carbon Analogue  
 Abstract    In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong 0-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4 a and 4 b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ^4b). 
  Reference    Z. Naturforsch. 38b, 738—746 (1983); eingegangen am 5. Januar 1983 
  Published    1983 
  Keywords    Sila-Substitution, Crystal and Molecular Structure, Antimuscarinic and Papaverine-Like Activity 
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 TEI-XML for    default:Reihe_B/38/ZNB-1983-38b-0738.pdf 
 Identifier    ZNB-1983-38b-0738 
 Volume    38