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1979 (1)
1Author    R. Tacke, M. Strecker, W. S. Sheldrick, E. Heeg, B. Berndt, K. M. KnapsteinRequires cookie*
 Title    Sila-Pharmaka, 14. Mitt. [1] Darstellung und Eigenschaften sowie Kristall-und Molekülstruktur von Sila-Difenidol Sila-Drugs, 14 th Communication [1] Preparation and Properties as well as Crystal and Molecular Structure of Sila-Difenidol  
 Abstract    Sila-difenidol (6 b), a sila-analogue of the drug difenidol (6 a), was synthesized according to Scheme 1. 6 b and its new precursors 3 and 5 were characterized by their physical and chemical properties, and their structures confirmed by elementary analyses, *H NMR and mass spectroscopy. 6 b crystallizes orthorhombic P 2i 2i 2i with a — 11.523(1), b = 14.366(4), c = 11.450(1) A, Z = 4, Dber = 1.14 gcm-3. The structure was refined to fi = 0.050 for 1897 reflexions. A strong nearly linear intramolecular 0-H---N hydrogen bond of 2.685 A is observed. The anticholinergic, histaminolytic and musculotropic spasmolytic activities of 6 a and 6 b are reported. 
  Reference    Z. Naturforsch. 34b, 1279—1285 (1979); eingegangen am 16. März 1979 
  Published    1979 
  Keywords    Sila-Difenidol, Syntheses, Crystal Structure, Molecular Structure, Biological Activity 
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 TEI-XML for    default:Reihe_B/34/ZNB-1979-34b-1279.pdf 
 Identifier    ZNB-1979-34b-1279 
 Volume    34