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1996 (1)
1995 (1)
1Author    M. Einrad Boll3, L. Utz, W.D W Eberb, A., Stam Reas, PflbRequires cookie*
 Title    The Response of Rat Serum Lipids to Diets of Varying Composition or Contaminated with Organochlorine Pesticides  
 Abstract    The effects of different diets (high carbohydrate, high protein, high fat) and diets contami­ nated with polychlorinated biphenyls (PCBs) and/or y-hexachlorocyclohexane (lindane) on the levels of serum triglycerides, cholesterol and phospholipids were investigated in Wistar rats. Serum triglyceride levels differed significantly among the diets, while those of cholesterol and phospholipids were much less affected by the diet composition. A change in diet compo­ sition resulted in a gradual adaptation to the lipid levels characteristic of the new diet with major variations including oscillations. There was, however, no specific component of a diet that could be associated with any specific change in serum lipids. While feed deprivation decreased the serum lipids (40-65% in 3 days), refeeding the starved animals caused pro­ nounced increases of the lipids that were different among the diets. The response of the triglyceride levels was the strongest (up to 1 0 times the starvation levels) followed by those of the phospholipids (4-fold) and cholesterol (2.5-fold). Response of the triglyceride levels peaked within 1 or 2 days of refeeding, whereas those of cholesterol and phospholipids took 4 days to reach the maximum. Feeding PCB-contaminated diets increased the serum lipids in a dose-dependent manner (15-250 ppm). Higher PCB concentrations were increasingly inhibitory (350 ppm) or overtly toxic (> 400 ppm). Elevated lipids returned to the starting levels immediately after peaking (triglycerides) or only after several days (cholesterol, phospholipids) but with an earlier onset at lower PCB concentrations. Refeeding starved animals with PCB-contaminated diets also increased the serum lipids dose-dependently. Feeding lindane-containing diets (50-150 ppm) as well as refeeding animals with lindane diets resulted in a considerable increase of the triglyceride levels, while cholesterol and phos-pohlipids increased much less. Higher lindane concentrations (250 ppm) were inhibitory. The outcome on serum lipid levels on feeding diets contam inated with both PCBs and lindane was basically additive. 
  Reference    Z. Naturforsch. 51c, 91—100 (1996); received Septem ber 9/November 6 1995 
  Published    1996 
  Keywords    Serum Lipids, Rat, Diet Composition Polychlorinated Biphenyls, y-Hexachlorocyclohexane (Lindane) 
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 TEI-XML for    default:Reihe_C/51/ZNC-1996-51c-0091.pdf 
 Identifier    ZNC-1996-51c-0091 
 Volume    51 
2Author    Meinrad Bolla, LutzW D W Eberbc, A.Ndreas StampflbRequires cookie*
 Title    The Effect of y-Hexachlorocyclohexane (Lindane) on the Activities of Liver Lipogenic Enzymes and on Serum Lipids in Rats  
 Abstract    The effect of dietary y-hexachlorocyclohexane (lindane) (5 0 -3 5 0 ppm, 0 .1 7 -1 .1 9 |imol/kg chow) on the activity of enzymes of lipogenesis, viz., fatty acid synthase (FAS; EC, citrate cleavage enzyme (CCE; EC, malic enzym e (ME; EC, glucose-6-phos-phate dehydrogenase (G 6 PDH; EC and 6-phosphogluconate dehydrogenase (PGDH; EC, and on serum lipid levels, was investigated in livers of 35-day-old male Wistar rats. Lindane (150 ppm) caused a substantial decline of enzym e activities within the first 24 h of treatment. The decrease was transient, however, and enzyme activities subsequently recov­ ered despite continuation of lindane feeding. The recovery of enzyme activities was compara­ tively fast in the case of ME, G 6 PDH and PG D H , but very slow with FAS and CCE. A ctivities of lipogenic enzymes decrease when animals are starved, and increase much beyond prestarvation levels upon subsequent refeeding. Lindane in the refeeding diet blunted this overshoot of FAS and CCE activities in a dose-dependent manner. In contrast, activities of ME, G 6 PD H and P G D H responded to low dietary lindane concentrations with a substantial stimulation of the increase o f activity, whereas at high lindane concentrations the overshoot was inhibited. According to their responses to lindane exposure, liver lipogenic enzymes could be grouped into 2 categories with FAS and CCE representing one and ME, G 6 PDH and PG D H representing the other group. Polychlorinated biphenyls (PCBs) in the diet caused basically opposite changes of the activities of the lipogenic enzymes. Co-administration o f lindane and PCBs resulted in an apparent cancellation of effects, suggesting that lindane and PCBs affect fatty acid synthesis at opposite points. Levels of the serum triglycerides were increased significantly as a result of lindane feeding, while serum cholesterol and phospholipid levels were only slightly elevated. The increase of serum triglyceride levels that is routinely observed after refeeding o f starved animals was stimulated even more by low concentrations o f lindane in the refeeding diet, but inhibited by high concentrations. 
  Reference    Z. Naturforsch. 50c, 135 (1995); received August 9/September 16 1994 
  Published    1995 
  Keywords    Lipogenic Enzymes, Rat Liver, y-H exachlorocyclohexane (Lindane), Enzyme Regulation, Serum Lipids 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0135.pdf 
 Identifier    ZNC-1995-50c-0135 
 Volume    50