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'Serum Lipids' in keywords Facet   Publication Year 1995  [X]
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1995[X]
1Author    Meinrad Bolla, LutzW D W Eberbc, A.Ndreas StampflbRequires cookie*
 Title    The Effect of y-Hexachlorocyclohexane (Lindane) on the Activities of Liver Lipogenic Enzymes and on Serum Lipids in Rats  
 Abstract    The effect of dietary y-hexachlorocyclohexane (lindane) (5 0 -3 5 0 ppm, 0 .1 7 -1 .1 9 |imol/kg chow) on the activity of enzymes of lipogenesis, viz., fatty acid synthase (FAS; EC 2.3.1.85), citrate cleavage enzyme (CCE; EC 4.1.3.8), malic enzym e (ME; EC 1.1.1.40), glucose-6-phos-phate dehydrogenase (G 6 PDH; EC 1.1.1.49) and 6-phosphogluconate dehydrogenase (PGDH; EC 1.1.1.44), and on serum lipid levels, was investigated in livers of 35-day-old male Wistar rats. Lindane (150 ppm) caused a substantial decline of enzym e activities within the first 24 h of treatment. The decrease was transient, however, and enzyme activities subsequently recov­ ered despite continuation of lindane feeding. The recovery of enzyme activities was compara­ tively fast in the case of ME, G 6 PDH and PG D H , but very slow with FAS and CCE. A ctivities of lipogenic enzymes decrease when animals are starved, and increase much beyond prestarvation levels upon subsequent refeeding. Lindane in the refeeding diet blunted this overshoot of FAS and CCE activities in a dose-dependent manner. In contrast, activities of ME, G 6 PD H and P G D H responded to low dietary lindane concentrations with a substantial stimulation of the increase o f activity, whereas at high lindane concentrations the overshoot was inhibited. According to their responses to lindane exposure, liver lipogenic enzymes could be grouped into 2 categories with FAS and CCE representing one and ME, G 6 PDH and PG D H representing the other group. Polychlorinated biphenyls (PCBs) in the diet caused basically opposite changes of the activities of the lipogenic enzymes. Co-administration o f lindane and PCBs resulted in an apparent cancellation of effects, suggesting that lindane and PCBs affect fatty acid synthesis at opposite points. Levels of the serum triglycerides were increased significantly as a result of lindane feeding, while serum cholesterol and phospholipid levels were only slightly elevated. The increase of serum triglyceride levels that is routinely observed after refeeding o f starved animals was stimulated even more by low concentrations o f lindane in the refeeding diet, but inhibited by high concentrations. 
  Reference    Z. Naturforsch. 50c, 135 (1995); received August 9/September 16 1994 
  Published    1995 
  Keywords    Lipogenic Enzymes, Rat Liver, y-H exachlorocyclohexane (Lindane), Enzyme Regulation, Serum Lipids 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0135.pdf 
 Identifier    ZNC-1995-50c-0135 
 Volume    50