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1	Author	Reinhold Tacke3, Dirk Reichel3, KurtG. Ünther5, StefanM. Ergetb	Requires cookie*
	Title	The First Liquid-Chromatographic Separation of the (/?)-and (S)-Enantiomers of a Chiral Silanol, Silane and Germane
	Abstract	The racemic mixtures of the muscarinic antagonists cyclohexyl(phenyl)(2-pyrrolidino-ethyl)silanol (sila-procyclidine, rac-1), cyclohexyl(hydroxymethyl)phenyl(2-piperidinoethyl)-silane (rac-2) and cyclohexyl(hydroxymethyl)phenyl(2-piperidinoethyl)germane (rac-3) were resolved by analytical liquid chromatography (H PLC) using chemically modified cellulose (1) or amylose (2, 3) as the chiral stationary phase. This chromatographic method was used for the quantitative determination of enantiomeric purity of the (R)-and (S)-enantiomers of 1 -3 , which were obtained by preparative resolution with chiral auxiliary agents. Further more, the enantiomeric purity o f these samples was established by 13C NM R studies using chiral shift reagents. According to these studies, the resolved antipodes of 1 -3 (obtained by preparative resolution) were almost enantiomerically pure [HPLC: >98.2% ee ((R)-3) to 99.4% ee ((tf)-l, (S)-l); NMR: > 97% ee].
	Reference	Z. Naturforsch. 50b, 568 (1995); received October 31 1994
	Published	1995
	Keywords	Chiral Silanol, Chiral Silane, Chiral Germane, Liquid Chromatography, Separation o f Enantiomers
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	TEI-XML for	default:Reihe_B/50/ZNB-1995-50b-0568.pdf
	Identifier	ZNB-1995-50b-0568
	Volume	50

2	Author	Z. Naturforsch	Requires cookie*
	Title	Oligophosphan-Liganden, XL*
	Abstract	fra/i.s-Cyclopentan-l,2-diyl-bis(dicyclohexylphosphan) und frans-Norbornan-2,3-diyl-bis(dicyclohexylphosphan): Synthese und Enantiomerentrennung. Reaktionen von [/ra/w-C5H8(PCy2)2]PtH(CH2CMe3) mit C -H-Bindungen unter achiralen und chiralen Bedingungen O ligophosphine Ligands, XL*. rra«s-C yclopentane-l ,2-diyl-bis(dicyclohexylphosphine) and rra/is-N orbornane-2,3-diyl-bis(dicyclohexylphosphine): Synthesis and Separation of E nantiom ers. R eactions of [rra/i5-C5H 8(P C y2)2]P tH (C H 2C M e3) with C -H Bonds u nder A chiral and Chiral Conditions A n d re a S aare3, Lutz D ahlenburg5 The bis(dicyclohexylphosphines) rra/i5-C5H8(PCy2)2 (1) and /ratts-C7H 10(PCy2) 2 (11)
	Reference	Z. Naturforsch. 50b, 1009—1017 (1995); eingegangen am 11. Januar 1995
	Published	1995
	Keywords	Chiral Bis(phosphine), Separation o f Enantiomers, Platinum Complexes, Activation of C -H
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	TEI-XML for	default:Reihe_B/50/ZNB-1995-50b-1009.pdf
	Identifier	ZNB-1995-50b-1009
	Volume	50