| 1 | Author
| Reinhold Tacke3, Dirk Reichel3, KurtG. Ünther5, StefanM. Ergetb | Requires cookie* | | Title
| The First Liquid-Chromatographic Separation of the (/?)-and (S)-Enantiomers of a Chiral Silanol, Silane and Germane  | | | Abstract
| The racemic mixtures of the muscarinic antagonists cyclohexyl(phenyl)(2-pyrrolidino-ethyl)silanol (sila-procyclidine, rac-1), cyclohexyl(hydroxymethyl)phenyl(2-piperidinoethyl)-silane (rac-2) and cyclohexyl(hydroxymethyl)phenyl(2-piperidinoethyl)germane (rac-3) were resolved by analytical liquid chromatography (H PLC) using chemically modified cellulose (1) or amylose (2, 3) as the chiral stationary phase. This chromatographic method was used for the quantitative determination of enantiomeric purity of the (R)-and (S)-enantiomers of 1 -3 , which were obtained by preparative resolution with chiral auxiliary agents. Further more, the enantiomeric purity o f these samples was established by 13C NM R studies using chiral shift reagents. According to these studies, the resolved antipodes of 1 -3 (obtained by preparative resolution) were almost enantiomerically pure [HPLC: >98.2% ee ((R)-3) to 99.4% ee ((tf)-l, (S)-l); NMR: > 97% ee]. | | |
Reference
| Z. Naturforsch. 50b, 568 (1995); received October 31 1994 | | |
Published
| 1995 | | |
Keywords
| Chiral Silanol, Chiral Silane, Chiral Germane, Liquid Chromatography, Separation o f Enantiomers | | |
Similar Items
| Find | | DEBUG INFO
| | | | TEI-XML for
| default:Reihe_B/50/ZNB-1995-50b-0568.pdf | | | Identifier
| ZNB-1995-50b-0568 | | | Volume
| 50 | |
2 | Author
| Z. Naturforsch | Requires cookie* | | Title
| Oligophosphan-Liganden, XL*  | | | Abstract
| fra/i.s-Cyclopentan-l,2-diyl-bis(dicyclohexylphosphan) und frans-Norbornan-2,3-diyl-bis(dicyclohexylphosphan): Synthese und Enantiomerentrennung. Reaktionen von [/ra/w-C5H8(PCy2)2]PtH(CH2CMe3) mit C -H-Bindungen unter achiralen und chiralen Bedingungen O ligophosphine Ligands, XL**. rra«s-C yclopentane-l ,2-diyl-bis(dicyclohexylphosphine) and rra/is-N orbornane-2,3-diyl-bis(dicyclohexylphosphine): Synthesis and Separation of E nantiom ers. R eactions of [rra/i5-C5H 8(P C y2)2]P tH (C H 2C M e3) with C -H Bonds u nder A chiral and Chiral Conditions A n d re a S aare3, Lutz D ahlenburg5 * The bis(dicyclohexylphosphines) rra/i5-C5H8(PCy2)2 (1) and /ratts-C7H 10(PCy2) 2 (11) | | |
Reference
| Z. Naturforsch. 50b, 1009—1017 (1995); eingegangen am 11. Januar 1995 | | |
Published
| 1995 | | |
Keywords
| Chiral Bis(phosphine), Separation o f Enantiomers, Platinum Complexes, Activation of C -H | | |
Similar Items
| Find | | DEBUG INFO
| | | | TEI-XML for
| default:Reihe_B/50/ZNB-1995-50b-1009.pdf | | | Identifier
| ZNB-1995-50b-1009 | | | Volume
| 50 | |
|