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1987 (1)
1Author    H. Eikmeier, H. J. RehmRequires cookie*
 Title    Semicontinuous and Continuous Production of Citric Acid with Immobilized Cells of Aspergillus niger  
 Abstract    The citric acid excretion of Ca-alginate-immobilized cells of Aspergillus niger in batch culture decreased with a half-time of approximately 19 days. Reactivation of the biocatalysts by regenera­ tion in growth medium was possible, but it was followed by a submerged sporulation of the fungus, and medium was highly contaminated with free cells. Citric acid production could better be prolonged by semicontinuous cultivation with medium exchange every 7 or 14 days, respective­ ly. After 32 days the remaining activity in semicontinuous culture was 1.4-fold higher than in comparable batch experiments. Similar improvements were obtained with a continuous process at a dilution rate of 0.125 v/v • d, whereby medium efflux 
  Reference    Z. Naturforsch. 42c, 408—413 (1987); received October 1 1986 
  Published    1987 
  Keywords    Aspergillus niger, Immobilized Cells, Citric Acid, Semicontinuous, Continuous 
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 TEI-XML for    default:Reihe_C/42/ZNC-1987-42c-0408.pdf 
 Identifier    ZNC-1987-42c-0408 
 Volume    42