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1997 (1)
1987 (1)
1Author    Zofia Plesnar3, Stanisław Malanowski3, Zenon Lotowskib, JacekW. Morzyckib, Jadwiga Frelek, Jacek WójcikdRequires cookie*
 Title    Stereospecific Association of C-20 Epimers of 3/?-Hydroxy-16-oxo-24-nor-17-azachol-5-eno-23-nitryle  
 Abstract    The cryoscopic measurements show that title compounds are strongly associated in CHC13 solutions. The association of the 20 R epimer is distinctly less pronounced than that of the 205 epipmer. Self-association of the 205 epimer leads to the formation of very large com­ plexes. The 20 R epimer forms associates via water molecules. The dissimilarity may be ex­ plained in terms of different accessibility of the lactam carbonyl groups in the two epimers for the association. It is proposed that the association process is controlled by the configura­ tion at the carbon atom C(20) and conformation around the C(20)-C(22) bond. Populations of side chain conformations of both epimers were determined by means of proton nuclear magnetic resonance. It was found for the 20 R epimer that the t and the -g rotamers are almost equally populated, and the rotamer +g is excluded. For the 205 epimer the +g rotamer predominates over the t one, and the -g rotamer is excluded. The N M R data are fully consistent with the results of the molecular modelling studies. 
  Reference    Z. Naturforsch. 52b, 749—756 (1997); received 
  Published    1997 
  Keywords    Self-Association, Cryoscopic Measurements, Conformational Analysis, CD Spectra, Azasteroids 
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 TEI-XML for    default:Reihe_B/52/ZNB-1997-52b-0749.pdf 
 Identifier    ZNB-1997-52b-0749 
 Volume    52 
2Author    A. Lberto Mazzini, R. Oberto FavillaRequires cookie*
 Title    The Effect of Guanidinium Chloride on the Self-Association of Bovine Liver Glutamate Dehydrogenase: A Gel Filtration Study  
 Abstract    The associative behaviour of bovine liver glutamate dehydrogenase has been studied by gel chrom atography at neutral pH in 1 m guanidinium chloride and 1 m sodium chloride. In guanidinium chloride both the elution volume and the elution profile of the enzyme are independ­ ent of protein concentration, whereas in sodium chloride they are strongly dependent on it. In NaCl the enzyme behaves as expected according to the well established random association m odel, w hereas in guanidinium chloride it appears to have completely lost the self-associative property. F urtherm ore, since the elution volume of the enzyme in guanidinium chloride corre­ sponds to that of an hexamer, trim er formation reported to occur in these conditions is not confirmed !?'7 this technioue 
  Reference    Z. Naturforsch. 42c, 217 (1987); received O ctober 17 1986 
  Published    1987 
  Keywords    G lutam ate D ehydrogenase, Self-Association, Guanidine Chloride, Inactivation, Gel Filtration 
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 TEI-XML for    default:Reihe_C/42/ZNC-1987-42c-0217.pdf 
 Identifier    ZNC-1987-42c-0217 
 Volume    42