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'Rock Key Equilibria' in keywords Facet   section ZfN Section B  [X]
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1998 (1)
1Author    Martin Jäger1, Paul Schuler1, HartmutB. Stegmann, Antal RockenbauerbRequires cookie*
 Title    Molecular Recognition Analyzed by Observing Intramolecular Interconversion with E PR Spectroscopy  
 Abstract    Molecular recognition between Rebek's cleft R and 4-(2-benzimidazolyl)-aminomethyl-2,6-di-rm-butyl-phenol (Bi) is investigated by means of EPR spectroscopy. Their specific inter-molecular interactions are distinguished from non-specific interactions represented by mere protonation on addition of benzoic acid. Both interactions are related to intramolecular in­ terconversions at the CQ-atom of Bi*, where a two-jump mechanism is found for free and protonated Bi* and a two-site exchange for the complexed ligand. While NMR spectroscopy indicates the existence of 1:1 and 1:2 receptor-substrate complexes, the faster time scale of EPR spectroscopy allows to identify one 1 : 2 as well as three 1 : 1 associates and to elucidate their formation conditions. Based upon the corresponding hf parameters, binding modes and sites are proposed for the key-in-the-lock system. 
  Reference    Z. Naturforsch. 53b, 1511—1519 (1998); received July 22 1998 
  Published    1998 
  Keywords    Rock-Key-Equilibria, Spin Labeling, Molecular Dynamics 
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 TEI-XML for    default:Reihe_B/53/ZNB-1998-53b-1511.pdf 
 Identifier    ZNB-1998-53b-1511 
 Volume    53