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1995 (1)
1Author    V. Kettmann, J. SivýRequires cookie*
 Title    A Receptor Interaction Model for Phenylcarbamate Local Anesthetics  
 Abstract    We report here a molecular modeling study of selected conformationally constrained phenylcarbamate local anesthetics in relation to the available pharmacological data that enabled us to develop a receptor-interaction model for this class of drugs. The validity of the model was confirmed on other semirigid analogues prepared for this study. The results suggest that the phenyl ring is most likely involved in a stacking interaction with a complementary receptor site and the tertiary ammonium group is capable of both hydrogen bonding and lipophilic interactions. 
  Reference    Z. Naturforsch. 50c, 708—714 (1995); received May 22/June 17 1995 
  Published    1995 
  Keywords    Local Anesthetics, Phenylcarbamates, Molecular Modeling, Receptor Model 
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 TEI-XML for    default:Reihe_C/50/ZNC-1995-50c-0708.pdf 
 Identifier    ZNC-1995-50c-0708 
 Volume    50