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1997 (1)
1Author    M. Alvarez De Sotomayor, M.D H Errera, C. Perez-Guerrero, E. M. ArhuendaRequires cookie*
 Title    Uterine Relaxant Effect of Zolpidem: A Comparison with Other Smooth Muscle Relaxants  
 Abstract    Zolpidem is an imidazopyridine sedative-hypnotic which interacts with central benzodia-zepine-receptors. To examine its effects on uterine smooth muscle we have com pared with those obtained by diltiazem, papaverine and diazepam on different experimental models. The IC50 values obtained indicate similar behaviour of zolpidem and diazepam. They showed more active against the spontaneous contractions and those induced by KC1 (60 mM) or by CaCl2 (0.01-10 mM) in Ca2+-free depolarizing medium than against acetylcholine (0.1 mM)-induced contractions. Both of them also showed more effectiveness against the tonic com ponent of the acetylcholine-evoked contraction than against the phasic one. All the drugs tested were less powerful against contractions induced by oxytocin than against those induced by other agonists. This observation let us speculate that the mechanism of action of zolpidem may be related to an action on Ca2+ influx through voltage-dependent Ca2+channels due to an interaction with low affinity receptor located at the plasmalemma as has been suggested for diazepam. 
  Reference    Z. Naturforsch. 52c, 687—693 (1997); received May 12/June 26 1997 
  Published    1997 
  Keywords    Zolpidem, Benzodiazepines, Rat Uterus, Calcium Channels 
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 TEI-XML for    default:Reihe_C/52/ZNC-1997-52c-0687.pdf 
 Identifier    ZNC-1997-52c-0687 
 Volume    52