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1972 (1)
1Author    G. SegewitzRequires cookie*
 Title    Liganden-und Isotopenaustausch im System: Serumproteine — Zink — Polyaminopolycarbonsäuren Ligand and Isotope Exchange in the System: Serum Proteins — Zinc — Polyaminopolycarbonic Acids  
 Abstract    In vitro-studies show that the Ca-chelates of EDTA and DTPA are equally effective in removing Zn from the proteins and that the Zn-protein pool is composed of several fractions with different stabilities. Only a small fraction of the protein-bound Zn can be labelled by 65 Zn in vitro and, as to the mobilization of 65 Zn, Ca-DTPA was found to be 20 times more effective than equimolar Ca-EDTA. The isotope exchange between Zn-DTPA and protein-bound 65 Zn is an extremely fast reaction whereas in the case of Zn-EDTA a sluggish exchange takes place. The analysis of the results led to conclusion that the ligand and isotope exchange reactions in the case of EDTA proceed via the free Zn 2+ -ion; with the high-dentate DTPA, however, the formation of ternary and mixed complexes plays an important role. The implications of the findings as related to the toxi-city of the Ca-chelates are discussed. 
  Reference    (Z. Naturforsch. 27b, 1370—1375 [1972]; eingegangen am 14. Juli 1972) 
  Published    1972 
  Keywords    Zinc, Radiozinc, Proteins, Ethylenediaminetetraacetate, Diethylenetriaminepentaacetate 
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 TEI-XML for    default:Reihe_B/27/ZNB-1972-27b-1370.pdf 
 Identifier    ZNB-1972-27b-1370 
 Volume    27