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1987 (1)
1Author    Ann Herm, Eckhard Frister, SchlimmeRequires cookie*
 Title    RingÖffnungsreaktionen an bioreaktiven Lactamsystemen Ring Opening Reactions of Bioreactive Lactam Systems  
 Abstract    l-ß-D -R ibofuranosylpyrrolidin-2,5-dione (9) was synthesized by ribosylation o f N-silylated succinimide (7) with 1,2,3,5-tetra-O -acetyl-ß-D -ribofuranose in acetonitril in the presence o f tin tetrachloride. The com pounds 9, l-ß-D -ribofuranosyl-l-H -pyrrol-2,5-dione (5) and N-methyl-maleinimide (2) were converted with am m onia to the ring-opened com ponents 16,14 and 15. The bioreactivity o f the N -m aleinim ide derivatives 2 and 5 with respect to addition and ring-opening reactions with am ino acid side chains containing either thiol or am ino groups was shown in model reactions with glutathion (com pds. 17, 18) and lysine (com pds. 19, 20). The ring opening reaction o f 3 -m eth y l-3 -p h en y l-l-ß -D -rib o fu ra n o sy lp y rro lid in -2 . d em onstratin g the p o ssib ility o f g ly co su c cin y la tio n o f 
  Reference    Z. Naturforsch. 42c, 603 (1987); received D ecem ber 15 1986/February 11 1987 
  Published    1987 
  Keywords    Lactam Systems, Silylation, R ibosylation, R ibonucleosides, Bioselectivity 
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 TEI-XML for    default:Reihe_C/42/ZNC-1987-42c-0603.pdf 
 Identifier    ZNC-1987-42c-0603 
 Volume    42