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1998 (1)
1Author    Stylianos Tsakiris3, Panagiota Kouniniotou-Krontiri3, KleopatraH. Schulpisb, JohnC. Stavridis3Requires cookie*
 Title    L-Phenylalanine Effect on Rat Brain Acetylcholinesterase and Na+,K+-ATPase  
 Abstract    The effect of different L-phenylalanine (Phe) concentrations (0 .1 -1 2 .1 m M) , on acetylcho­ linesterase (A C h E) and N a+,K +-ATPase activities of brain homogenate and pure enzymes, was investigated at 37 °C. A C h E and Na+,K +-ATPase activities were determined according to Ellman G. -6 1 3) respectively, after preincubation with Phe. A C h E activity in brain homogenate or in pure eel E.electricus enzyme showed a decrease, which reached up to 18% with concentrations of 0 .9 -1 2 .1 m M . Brain homogenate N a+,K +-A TPase activity showed an increase 1 6 -6 5 % with 0 .2 4 -0 .9 mM of Phe, while an activity increase of 6 0 -6 5 % appeared with 0 .9 -1 2 .1 mM of Phe. Pure en­ zyme activity (from porcine cerebral cortex) was not affected by high Phe concentrations, while it was increased by low concentrations. The above results suggest: a) A direct effect of Phe on A C h E , b) A direct effect of low Phe concentrations and an indirect effect of high ones on Na+,K +-ATPase. 
  Reference    Z. Naturforsch. 53c, 163 (1998); received September 22/D ecem ber 15 1997 
  Published    1998 
  Keywords    L-Phenylalanine, R at Brain, Acetylcholinesterase, N a+, K +-ATPase, Mg2+-ATPase 
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 TEI-XML for    default:Reihe_C/53/ZNC-1998-53c-0163.pdf 
 Identifier    ZNC-1998-53c-0163 
 Volume    53