| | 1 | Author
| Martin Wenzel, G. Ert Schachschneider | Requires cookie* | | | Title
| Analoga des Hippurans: [103RulRuthenocenoyl-glycin-Derivate. Synthese, Organ-Verteilung und Clearance Analogue of Hippuran: Labelled Ruthenocenoyl-glycin. Synthesis, Organ Distribution and Clearance  | | | | Abstract
| The analogue o f hippuric acid, ruthenocenoyl-glycine was synthesized and labelled with the y-emitter 103Ru. As a by-product o f the synthesis the labelled diam ide from ruthenocene-dicarbonic acid and glycine was gained. With these ruthenocene derivatives the organ distribu tions in mice and rats were measured. All ruthenocene-glycine derivatives showed prim ary a high kidney accum ulation followed by very rapid renal excretion. After application o f the cytostatic PtCl2(N H 3) 2, causing toxic effects in the kidney o f m ice, the excretion of ruthenocenoyl-glycine is decreased. Biochem ical data suggest the use of labelled ruthenocenoyl-glycine as a substitute for Iodo-labelled hippuran. | | | |
Reference
| Z. Naturforsch. 38c, 806 (1983); received May 2/Ju ly 19 1983 | | | |
Published
| 1983 | | | |
Keywords
| Ruthenium Isotopes, Metallocenes, Kidney, R adiopharm aceuticals, Organ D istribution | | | |
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| default:Reihe_C/38/ZNC-1983-38c-0806.pdf | | | | Identifier
| ZNC-1983-38c-0806 | | | | Volume
| 38 | |
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