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1999 (1)
1Author    Halina Kleszczyńska3, MałgorzataO. Święcimskab, Janusz Sarapuk3, Stanisław Witekb, Stanisław Przestalski3Requires cookie*
 Title    Protective Effect of Quaternary Piperidinium Salts on Lipid Oxidation in the Erythrocyte Membrane  
 Abstract    A new series of amphiphilic compounds with incorporated antioxidant functional group has been investigated. Piperidinium bromides, differing in the alkyl chain length (8, 10, 12, 14 and 16 carbon atoms in the chain) were synthesised to protect biological and/or model membranes against peroxidation and following negative consequences. Their antioxidant ac­ tivity was studied with erythrocytes subjected to UV radiation. The salts used inhibited lipid oxidation in the erythrocyte membrane. The degree of this inhibition depended on the alkyl chain length of the bromide used and increased with increasing alkyl chain length. A compar­ ison of the results obtained for piperidinium bromides with those obtained for the widely used antioxidant 3,5-di-r-butyl-4-hydroxytoluene (BH T) revealed that only two shortest alkyl chain salts were less efficient than BH T in protecting erythrocyte membranes. A similar comparison with antioxidant efficiency of flavonoids extracted from Rosa rugosa showed that they protected the membranes studied more weakly than the least effective eight-carbon alkyl chain piperidinium bromide. The three compounds of longest alkyl chains were the most active antioxidants. Their activities did not differ significantly. 
  Reference    Z. Naturforsch. 54c, 424 (1999); received January 22/February 24 1999 
  Published    1999 
  Keywords    Antioxidants, Lipid Oxidation, Erythrocyte Membrane, Quaternary Piperidinium Salts, Flavonoids 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0424.pdf 
 Identifier    ZNC-1999-54c-0424 
 Volume    54