| | 1 | Author
| TeresaE. Krai, Janina Kuczera, Stanislaw Przestalski, TeresaE. Krai | Requires cookie* | | | Title
| Organometallics and Quaternary Ammonium Salts Affect Calcium Ion Desorption from Lecithin Liposome Membranes  | | | | Abstract
| The objective of the present work was to compare the effects of groups o f tin and lead organometallic com pounds and their mixtures with amphiphilic quaternary ammonium salts (Q A S) on the process of calcium ion desorption from lecithin liposom e membranes, as de pendent on the properties of the hydrophilic and hydrophobic parts o f QAS. In the investiga tions the method of radioactive labels was applied. Synergism and antagonism in the action of both groups o f compounds were found. The effectiveness o f the cooperation depended more on chain length o f Q A S compounds than on the size and polarity of their hydrophobic parts. The most effective of all compounds studied was a the mixture of benzyldimethylam-monium chloride in a mixture with tripropyltin. Since the rate of calcium desorption proved to be a good measure o f efficacy of biologically active surfactants, it seem s that the conclu sions reached in this paper may be useful for choosing compounds which are able to decon taminate the environm ent polluted with heavy metals. | | | |
Reference
| Z. Naturforsch. 56c, 395 (2001); received September 7 2000/January 26 2001 | | | |
Published
| 2001 | | | |
Keywords
| Organometallics, Quaternary Ammonium Salts, Cooperative Effect | | | |
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| default:Reihe_C/56/ZNC-2001-56c-0395.pdf | | | | Identifier
| ZNC-2001-56c-0395 | | | | Volume
| 56 | |
| 2 | Author
| H. Kleszczyńska3, M. O. Święcimskab, S. W. Itekb, S. Przestalskia | Requires cookie* | | | Title
| Inhibition of Lipid Peroxidation in the Erythrocyte Membrane by Quaternary Morpholinium Salts with Antioxidant Function | | | | Abstract
| The antioxidant activity of five new compounds from a group of quaternary ammonium salts with antioxidant function has been investigated. The effect of the compounds on the degree of lipid oxidation in the erythrocyte membrane subjected to UV radiation was studied. It was found that all the salts used decreased oxidation of the lipids in the erythrocyte mem brane. The antioxidant activity of the ammonium salts studied increased with their alkyl chain length. Three compounds with the longest alkyl chains were the most active antioxidants, and their antioxidant properties were comparable to those of a flavonoid extracted from haw thorn. The antioxidant effectiveness of the ten-carbon alkyl chain compound was comparable with that of the known antioxidant 3,5-di-t-butyl-4-hydroxytoluene (BHT). The least effective antioxidant studied proved to be the eight-carbon alkyl chain compound. The effect of these compounds on fluidity of the erythrocyte membrane has been studied, and for all an increase of fluidity of the membrane was observed. The changes in erythrocyte ghosts fluidity de pended both on concentration and type of compound. A fluorimetric study also indicated that rigidity of the erythrocyte membrane increased with degree of its oxidation, but with antioxidants present membrane rigidity increased less. | | | |
Reference
| Z. Naturforsch. 53c, 425—430 (1998); received January 26/March 16 1998 | | | |
Published
| 1998 | | | |
Keywords
| Antioxidants, Lipid Oxidation, Erythrocyte Ghost, Quaternary Ammonium Salts, Plant Flavonoid | | | |
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| default:Reihe_C/53/ZNC-1998-53c-0425.pdf | | | | Identifier
| ZNC-1998-53c-0425 | | | | Volume
| 53 | |
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