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'Quaternary Ammonium Salts' in keywords Facet   Publication Year 1998  [X]
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1Author    H. Kleszczyńska3, M. O. Święcimskab, S. W. Itekb, S. PrzestalskiaRequires cookie*
 Title    Inhibition of Lipid Peroxidation in the Erythrocyte Membrane by Quaternary Morpholinium Salts with Antioxidant Function  
 Abstract    The antioxidant activity of five new compounds from a group of quaternary ammonium salts with antioxidant function has been investigated. The effect of the compounds on the degree of lipid oxidation in the erythrocyte membrane subjected to UV radiation was studied. It was found that all the salts used decreased oxidation of the lipids in the erythrocyte mem­ brane. The antioxidant activity of the ammonium salts studied increased with their alkyl chain length. Three compounds with the longest alkyl chains were the most active antioxidants, and their antioxidant properties were comparable to those of a flavonoid extracted from haw­ thorn. The antioxidant effectiveness of the ten-carbon alkyl chain compound was comparable with that of the known antioxidant 3,5-di-t-butyl-4-hydroxytoluene (BHT). The least effective antioxidant studied proved to be the eight-carbon alkyl chain compound. The effect of these compounds on fluidity of the erythrocyte membrane has been studied, and for all an increase of fluidity of the membrane was observed. The changes in erythrocyte ghosts fluidity de­ pended both on concentration and type of compound. A fluorimetric study also indicated that rigidity of the erythrocyte membrane increased with degree of its oxidation, but with antioxidants present membrane rigidity increased less. 
  Reference    Z. Naturforsch. 53c, 425—430 (1998); received January 26/March 16 1998 
  Published    1998 
  Keywords    Antioxidants, Lipid Oxidation, Erythrocyte Ghost, Quaternary Ammonium Salts, Plant Flavonoid 
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 TEI-XML for    default:Reihe_C/53/ZNC-1998-53c-0425.pdf 
 Identifier    ZNC-1998-53c-0425 
 Volume    53