| | 1 | Author
| E. Schauenstein, J. Gölles, H. W. Altersdorf Er, R. J. Sdiaur | Requires cookie* | | | Title
| Association between the Doubling Time of Various Cells and Tissues, and the SH-Content of Their Soluble Proteins  | | | | Abstract
| The num ber of SH-groups of the soluble proteins (Prot-SH) of 12 different types of animal tum ors and of cultivated chicken fibroblasts increases with decreasing doubling tim e (id) ■ Between Prot-SH and id an inverse association was found with a significance level of 99.5%. After 30 min incubation in vitro, 4-hydroxypentenal (H PE) reacts with different am ounts of the Prot-SH of the investigated cells and tissues. It was found that the absolute, as well as the per cental amounts of HPE-reactive Prot-SH increase with decreasing fd > each of the respective inverse associations was found to be highly significant. The tum ors were collected in three groups, each with a corresponding range of td and a mean value for Prot-SH . Taking the Prot-SH of the slowest growing tissue (DENA-hepatoma) as the reference value, the increm ents of Prot-SH were cal culated for each of the three groups and were found to be strikingly sim ilar to the num ber of HPE-reactive Prot-SH. The single Prot-SH increm ents of the diverse cell and tissue types compared with DENA-hepatoma were found to be highly significantly and inversely associated with the respective Prot-SH decreases caused by H PE. Hence it may be concluded that H PE reacts preferably with those of the Prot-SH which are of some functional importance for tum or growth and, moreover that the attack on those thiols is the more effective the faster the tumor is growing. | | | |
Reference
| Z. Naturforsch. 33c, 79 (1978); received A pril 5/O ctober 24 1977 | | | |
Published
| 1978 | | | |
Keywords
| Protein-SH-Groups, Tumors, Doubling Time | | | |
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| default:Reihe_C/33/ZNC-1978-33c-0079.pdf | | | | Identifier
| ZNC-1978-33c-0079 | | | | Volume
| 33 | |
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