Go toArchive
Browse byFacets
Bookbag ( 0 )
'Primin' in keywords Facet   section ZfN Section B  [X]
Results  1 Item
Sorted by   
Publication Year
1993 (1)
1Author    WilfriedA. Königa, Holger Faascha, Holger Heitsch3, Cornelia Colberga, BjörnM H AusenRequires cookie*
 Title    Synthese von seitenkettenmodifizierten Analogen des Allergens Primin Synthesis of Side-Chain-Modified Analogues of the Allergen Primin  
 Abstract    Benzoquinones such as primin (2-methoxy-6-pentyl-l ,4-benzoquinone) from Primula ob-conica H A N C E (Primulaceae) are known to be strong sensitizers and thus the source of severe allergic contact derm atitis (cell-mediated type of allergy). In order to determine the relation­ ship between sensitizing capacity and chemical structure the synthesis of 19 side-chain-modi-fied analogues of primin was carried out. With each of these primin derivatives 10 guinea pigs were sensitized using a modified FCA-m ethod (FCA = Freund's complete adjuvant). Elicita­ tion was done open epicutaneously with 0.001 molar concentrations. In these sensitization ex­ periments 2-methoxy-6-alkyl-l ,4-benzoquinones (chain length C , -C 15) showed ascending sen­ sitizing potency with increasing number of the side chain carbon atom s reaching maximum activity at an alkyl chain of 10 to 11 carbons. Beyond this point a decrease o f the sensitizing potency in correlation with a further prolongation of the side chain was observed. 
  Reference    Z. Naturforsch. 48b, 387—393 (1993); eingegangen am 13. Juli 1992 
  Published    1993 
  Keywords    Primin, 6-Alkyl-2-methoxy-l, 4-benzoquinones, Allergens, 'H N M R Spectra, Mass Spectra 
  Similar Items    Find
 TEI-XML for    default:Reihe_B/48/ZNB-1993-48b-0387.pdf 
 Identifier    ZNB-1993-48b-0387 
 Volume    48