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1983 (1)
1Author    R. Maschler, C. J. Smith, J. C. Allen, H. R. MaurerRequires cookie*
 Title    Elucidation of the Different Effects of Polyamines and Other Naturally-Occurring Inhibitors of Cell Proliferation (Chalones) on T-Lymphocyte and Granulocyte Colony Growth in vitro  
 Abstract    Using T-lymphocyte and granulocyte colony assays with truly proliferating cells the effects of the polyamine spermine and o f other naturally-occurring inhibitors of cell proliferation have been differentiated. It has been confirmed that spermine, in the presence o f fetal calf serum, is a potent inhibitor of cell proliferation. This inhibition could be reversed by the addition o f either 3-hydroxybenzyl-oxyamine or 4-bromo-3-hydroxybenzyl-oxyamine, both of which are inhibitors of the polyamine oxidase. In comparison, fractions isolated from calf thymus were shown to inhibit lymphocyte, but not granulocyte colony growth, indicating their tissue specificity and lymphocyte chalone activity. Further this inhibition was not reversed by polyamine oxidase inhibitors demonstrating that polyamines were not the inhibitory principles in this preparation. 
  Reference    Z. Naturforsch. 38c, 74—7 (1983); received February 24/August 24 1982 
  Published    1983 
  Keywords    Polyamines, Lymphocyte Responsiveness, Polyamine Oxidase Inhibitors, Lymphocyte Chalone 
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 TEI-XML for    default:Reihe_C/38/ZNC-1983-38c-0074.pdf 
 Identifier    ZNC-1983-38c-0074 
 Volume    38