| | 1 | Author
| Gabriele Luckner, Paul Renz | Requires cookie* | | | Title
| On the Phospholipase Activity in Bovine Seminal Vesicles and Its Possible Role in the Regulation of the Prostaglandin Biosynthesis  | | | | Abstract
| A phospholipid mixture was isolated from bovine seminal vesicle tissue. This phospholipid pre paration contained the following prostaglandin precursor fatty acids: 4.7 percent 5,8,11-eicosa-trienoic acid, 9.1 percent 5,8,11,14-eicosatetraenoic acid and 0.9 percent 5,8,11,14,17-eicosa-pentaenoic acid. With this phospholipid preparation as substrate phospholipase activity could be detected in different fractions of bovine seminal vesicle cells. The highest phospholipase activity was found in the microsomal fraction, less in the mitochondria and essentially no activity in the cytosol. With a microsome preparation (acetone powder) of bovine seminal vesicles the influence of certain effectors on the phospholipase activity was investigated. Prostaglandins E2 and F2a (10 5 m) showed 19 and 41 percent inhibition, DB-c-AMP (2 x 10—9 m) 54 percent, c-AMP (1 0 ~ 9 m) 22 percent, epinephrine (10—4 m) 60 percent, testosterone (10—5 m) 25 percent inhibition of the phos pholipase activity. Whereas ethanol exhibits also a strong inhibition on the phospholipase activity, it shows a pronounced activation of the prostaglandin synthetase. | | | |
Reference
| (Z. Naturforsch. 30c, 429 [1975]; received March 25 1975) | | | |
Published
| 1975 | | | |
Keywords
| Phospholipases, Phospholipids, Bovine Seminal Vesicles, Prostaglandins, Hormones | | | |
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| default:Reihe_C/30/ZNC-1975-30c-0429.pdf | | | | Identifier
| ZNC-1975-30c-0429 | | | | Volume
| 30 | |
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