Go toArchive
Browse byFacets
Bookbag ( 0 )
'Phosphates' in keywords Facet   section ZfN Section C  [X]
Results  2 Items
Sorted by   
Publication Year
1988 (1)
1975 (1)
1Author    PierreM. Ermier, Wilhelm HasselbachRequires cookie*
 Title    The Effect of Calcium and Phosphate on the Biphasic Calcium Uptake by the Sarcoplasmic Reticulum  
 Abstract    The amplitude of the fast uptake and the initial rate of the slow uptake increase with in­ creasing free calcium concentrations, up to 30 [xu. In that range, both processes are correlated to each other. At higher concentrations, the slow uptake is more inhibited than the fast uptake. The fast uptake shows a maximum amplitude which remains unchanged in the presence of phosphate. The slow uptake leads to a nearly complete depletion of the external calcium, and its rate is pro­ portional to the phosphate concentration, even at physiological range. The sarcoplasmic ATPase liberates inorganic phosphate and the slow uptake 
  Reference    (Z. Naturforsch. 30c, 777 [1975]; received July 17 1975) 
  Published    1975 
  Keywords    Sarcoplasmic Reticulum, Calcium, Phosphate, Flow Dialysis 
  Similar Items    Find
 DEBUG INFO      
 TEI-XML for    default:Reihe_C/30/ZNC-1975-30c-0777.pdf 
 Identifier    ZNC-1975-30c-0777 
 Volume    30 
2Author    Ryszard Stolarski, Piotr Lassota, Zygmunt Kazimierczuk, David ShugarRequires cookie*
 Title    Solution Conformations of Some Acyclo Nucleoside and Nucleotide Analogues of Antiviral Acyclonucleosides, and Their Substrate/Inhibitor Properties in Several Enzyme Systems  
 Abstract    Chemical and enzymatic procedures have been employed for the preparation of various phos-phorylated derivatives of the acyclonucleoside 9-(l,3-dihydroxy-2-propoxymethyl)adenine, an analogue of the active antiviral agent 9-(l,3-dihydroxy-2-propoxymethyl)guanine (DHPG). In combination with the previously reported 2',3'-seco nucleosides and their phosphates and cyclic phosphates (Stolarski et al., this made available a broad class of acyclonucleosides and nucleotides, the acyclic moieties of which are capable of mimicing the ribose and 2'-deoxyribose rings. The solution conformations of the foregoing were determined with the aid of 'H, 13 C and 31 P NMR, and compared with those of DHPG and 9-(hydroxyethoxymethyl)guanine (Acyclovir, ACV). Particular attention was devoted to conformations about C-O bonds in different acyclic fragments, which demonstrated well-defined differences between 2',3'-seco derivatives on the one hand (conformational "rigidity") and derivatives with DHP and AC acyclic chains on the other (rotation about the C(l')-0(4') bond). The overall results are in good general agreement with reported crystal structures, and are compared with those obtained by quantum mechanical calcu-lations. The conformational features of the various compounds are also discussed in relation to their substrate and/or inhibitor properties in a number of enzyme systems, including adenosine deamin-ase, phosphodiesterases, nuclease PI, 3'-nucleotidase and herpes virus type 1 thymidine kinase. Abbreviations: AC, 2-hydroxyethoxymethyl; DHP, 1,3-di-hydroxy-2-propoxymethyl; seco, 2',3'-seco or 1,5-dihydro-4-hydroxymethyl-3-oxapentyl-2-[R]; ACV, Acyclovir or AcycloG, 9-(2-hydroxyethoxymethyl)guanine; ACVMP, monophosphate of ACV; AC-Cyt, l-(2-hydroxyethoxy-methyl)cytosine, with similar connotations for AC-Ade and AC-Ura; DHPG, 9-(l,3-dihydroxy-2-propoxymethyl)-guanine; DHP-Ade, adenine analogue of DHPG; DHPGMP, monophosphate of DHPG; DHP-AdeMP, monophosphate of DHP-Ade; DHP-Ade-diP, 3',5'-diphosphate of DHP-Ade; DHP-Ade-3' : 5'-cMP, the 3':5'-cyclic monophosphate of DHP-Ade; secoA, 2',3'-secoadenosine or 9-(l,5-dihydro-4-hydroxymethyl-3-oxa-pentyl-2-[R])adenine, with similar connotations for other acyclonucleosides; seco-5'-GMP, 5'-monophosphate of secoG, and similarly for seco-5'-CMP and seco-5'-AMP; secoC-3' :5'-cMP, 2',3'-secocytidine-3' :5'-cyclic phos-phate, and similarly for secoA-3':5'-cMP; TK, thymidine kinase; cPDase, cyclic nucleotide phosphodiesterase. For purposes of simplicity, the abbreviated terms are used in the text, with the carbon atoms of the acyclic chains numbered as for the corresponding carbon atoms of the pentose ring, as shown in Scheme 1. 
  Reference    Z. Naturforsch. 43c, 231—242 (1988); received December 3 1987 
  Published    1988 
  Keywords    Acyclonucleosides, Phosphates, Cyclic Phosphates, Solution Conformations, Substrate/Inhibitor Properties 
  Similar Items    Find
 DEBUG INFO      
 TEI-XML for    default:Reihe_C/43/ZNC-1988-43c-0231.pdf 
 Identifier    ZNC-1988-43c-0231 
 Volume    43