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'Phosphates' in keywords Facet   Publication Year 1977  [X]
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 Title    Transphosphorylative Spin-Labeling Utilizing Diimidazolides of Pentavalent Phosphorus  
 Abstract    G e o r g e S o s n o v s k y a n d M a r i a K o n i e c z n y The reaction of the spin-labeled diimidazolide 1 with hydroxy and amino compounds was studied. Diimidazolide 1 was superior to the dichloridate 6 for the preparation of spin-labeled phosphates 3 and phosphorodiamidates 2. The spin-labeled phosphate 15 was synthesized through hydrolysis of 6 . Spin-labeled cyclophosphoramidates (10-13), analogs of the cytotoxic Endoxan, were prepared by the reaction of 1 and 6 with the appropriate difunctional nucleophile. Inductive effects of substituents in the imidazolyl m oiety on the transphosphorylation reaction were also studied. 0 0 0 0 R0p { N ^ f) 2 R O P (N r'r2)2 R 0P(0R> 2 RO PCIj I 2 3 6 0 o 1 1 / N OP (CH2)n N H 10 (n • 2 ,3) H 0 • II ,0 ROP r i i CH, ROP, n ' x h , 13 
  Reference    (Z. Naturforsch. 32b, 1048—1059 [1977]; received May 9 1977) 
  Published    1977 
  Keywords    Spin-labeled Imidazolides, Phosphates, Cyclophosphoramidates, Transphosphorylation, Phosphorodiamidates 
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 TEI-XML for    default:Reihe_B/32/ZNB-1977-32b-1048.pdf 
 Identifier    ZNB-1977-32b-1048 
 Volume    32