Go toArchive
Browse byFacets
Bookbag ( 0 )
'Pharmacological Properties' in keywords
Results  2 Items
Sorted by   
Publication Year
1983 (1)
1978 (1)
1Author    Reinhold Tacke, Roland NiednerRequires cookie*
 Title    Sila-Pharmaka, 9. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, I Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, I  
 Abstract    Organosilicon compounds 8, 9 and 10 with potential curare-like action and their precursors 5, 6 and 7 were synthesized for the first time. 5-10 were characterized by their physical and chemical properties, and their structures were confirmed by analyses, 1 H NMR and mass spectroscopy (only for 5-7). The pharmacological and toxicological data of 8, 9 and 10 are reported. 
  Reference    Z. Naturforsch. 33b, 412—416 (1978); eingegangen am 3. Februar 1978 
  Published    1978 
  Keywords    Silicon Compounds, Pharmacological Properties, Toxicological Properties, Curare-Like Activity 
  Similar Items    Find
 TEI-XML for    default:Reihe_B/33/ZNB-1978-33b-0412.pdf 
 Identifier    ZNB-1978-33b-0412 
 Volume    33 
2Author    Manfred Gerlach, Peter Jutzi, Johannes-Peter Stasch, Horst PrzuntekRequires cookie*
 Title    Synthese und pharmakologische Eigenschaften von silylierten Dopaminen und 4.4-Diphenylpiperidinen Synthesis and Pharmacological Properties of Silylated Dopamines and 4,4-Diphenylpiperidines  
 Abstract    Syntheses for the bis-O-trimethylsilylated (2), the tris-0,0,N-trimethylsilylated (3) and the tetrakis-0,0,N,N-trimethylsilylated dopamine (4) are described. The preparation of some N-trialkylsilylated 4,4-diphenylpiperidines 6-8 and of the N-triphenylsilylated piperidine 9 is also reported. The silylation of these neuropharmaca enhances their lipo-philic character. Preliminary pharmacological investigations show the desired central effect of these compounds. The silylated dopamines 3 and 4 influence positively the rigid akinetic syndrom, which was induced by reserpine. The silylated 4,4-diphenylpiperidines 6-9 show the same effect on the content of neurotransmitters in the rat brain as the Anti-parkinson drug l-ier£-butyl-4,4-diphenylpiperidine (budipine). 
  Reference    Z. Naturforsch. 38b, 237—242 (1983); eingegangen am 1. Oktoder 1982 
  Published    1983 
  Keywords    Silylated Dopamines, Silylated 4, 4-Diphenylpiperidines, Syntheses, Pharmacological Properties, Neuropharmaca 
  Similar Items    Find
 TEI-XML for    default:Reihe_B/38/ZNB-1983-38b-0237.pdf 
 Identifier    ZNB-1983-38b-0237 
 Volume    38