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'Phalloidin' in keywords
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1984 (1)
1979 (1)
1Author    HermannL. LotterRequires cookie*
 Title    Untersuchung der Struktur-Wirkungsbeziehung antihepatotoxischer Naturstoffe (Silybin-Antamanid) durch Röntgenstrukturanalyse  
 Abstract    Both, the flavonolignane silybin and the decapeptide antam anide, protect anim als against the mushroom poison phalloidin from Amanita species. The X-ray structures o f silybin and anta­ manide have been solved in previous studies. Here an attempt has been m ade to explain the antagonistic antihepatotoxic protection by sim ilar chem ical structure elem ents in the two compounds. It can be shown that two aromatic rings in a definite arrangement are essential for the attachment to the target structure o f the liver cell membrane. Com parable pharm acological tests are discussed. 
  Reference    Z. Naturforsch. 39c, 535 (1984); received Decem ber 2 1983/March 26 1984 
  Published    1984 
  Keywords    Silybin, Antamanide, Phalloidin, Structure Activity Relationship, A ntihepatotoxic Principle 
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 TEI-XML for    default:Reihe_C/39/ZNC-1984-39c-0535.pdf 
 Identifier    ZNC-1984-39c-0535 
 Volume    39 
2Author    Tjakko Stijve, Ruth SeegerRequires cookie*
 Title    Determination of a-, ß and y-Amanitin by High Performance Thin-Layer Chromatography in Amanita phalloides (Vaill. ex Fr.) Seer, from Various Origin  
 Abstract    A fast, sensitive high performance thin-layer chrom atographic method for the determ ination of a-, ß-, and y-amanitin in crude, m ethanolic extracts o f Amanita phalloides is described. The limit o f detection is 50 ng of each amanitin. W ith this method am anitin was determ ined in 24 pooled samples of Amanita phalloides, collect­ ed between 1970 and 1977 in G erm any and Switzerland. The total am anitin content varied be­ tween 2010 and 7300 mg/kg dry weight and the average value was 4430 m g/kg of which 43% was a-am anitin, 49% /?-amanitin and 8% y-amanitin. The origin of the fungi hardly influenced their am anitin content: in samples collected during the same year at different sites it fluctuated within a factor o f 1.7. The am anitin content of samples from the same site, but collected in different years, maximally varied within a factor o f 3.7. The partial decom position of am anitins during prolonged storage of the lyophilized samples undoubtedly contributed to this variation. Phalloidin, which was determined by conventional thin-layer-chrom atography, could not be de­ tected in a sample from 1970, whereas its concentration in m aterial collected during 1977 am ount­ ed to 2400 mg/kg dry weight. The toxicity of the samples (LD 50 o f lyophilized defatted methanolic extracts intravenously for mice) varied within a factor of 2.5. 
  Reference    Z. Naturforsch. 34c, 1133—1138 (1979); received July 9 1979 
  Published    1979 
  Keywords    Amanita phalloides, Amanitins, Phalloidin, M ushroom Poisoning, Chrom atography 
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 TEI-XML for    default:Reihe_C/34/ZNC-1979-34c-1133.pdf 
 Identifier    ZNC-1979-34c-1133 
 Volume    34