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'Peptides' in keywords Facet   section ZfN Section C  [X]
Facet   Publication Year 1999  [X]
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1999[X]
1Author    Toshiro Matsui, Tomoyuki Oki, Yutaka OsajimaRequires cookie*
 Title    Isolation and Identification of Peptidic a-Glucosidase Inhibitors Derived from Sardine Muscle Hydrolyzate  
 Abstract    We report here the isolation of a-glucosidase (A G H) inhibitory peptides derived from sardine muscle hydrolyzate, which was prepared by digestion with Bacillus licheniformis alka­ line protease. A s a result of reversed-phase HPLC purification, two A G H inhibitory peptides were isolated from a D EA E -Sephadex A-25 column eluate. The peptides were identified as follows: V al-Trp (IC50 = 22.6 mM) and T ry -T y r -P r o -L e u (IC50 = 3.7 mM). A G H inhibitory studies of T r y -T y r -P r o -L e u and its derivatives demonstrated the importance of the tri­ peptide chain length as well as the hydrophobic aromatic amino acid tyrosine at the N-terminus, aliphatic amino acids at the C-terminus, as well as an amide proton from the peptide chain at the middle position of the tri-peptide to develop AGH inhibition activity. 
  Reference    Z. Naturforsch. 54c, 259 (1999); received August 25/October 5 1998 
  Published    1999 
  Keywords    a-G lucosidase Inhibition, Diabetes, Sardine Muscle Hydrolyzate, Peptide 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0259.pdf 
 Identifier    ZNC-1999-54c-0259 
 Volume    54 
2Author    IvankaG. Stankova3, M. Ario, F. Simeonovb, Vera Maximova0, AngelS. Galabov0, EvgenyV. GolovinskydRequires cookie*
 Title    Synthesis and Anti-Virus Activity of Some Nucleosides Analogues  
 Abstract    New 3'-, 5'-, 5-bromo-2'-deoxyuridine (3 a -g) and 3'-, 5'-thymidine (4 a -i) analogues with amino acid and peptide residues were synthesized and evaluated for antiviral activity. The influence of long peptide chains, essential amino acids and the effect of this structural modifi­ cation on the antiviral activity has been also reported. Three 5-bromo-2'-deoxyuridine derivatives containing glycyl-, glycyl-glycyl-and glycyl-gly-cyl-glycyl-residues (3a, 3b, 3c) showed a strong activity against the herpes virus PsRV and a moderate one vs. HSV-1. The corresponding thymidine analogues were considerably less effective, and only com­ pounds 4d and 4h showed a borderline effect against PsRV. 
  Reference    Z. Naturforsch. 54c, 75—83 (1999); received August lO/October 20 1998 
  Published    1999 
  Keywords    5-Bromo-2'-Deoxyuridine, Thymidine, Amino Acids, Peptides, Antiherpes Activity 
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 TEI-XML for    default:Reihe_C/54/ZNC-1999-54c-0075.pdf 
 Identifier    ZNC-1999-54c-0075 
 Volume    54