| | 1 | Author
| Toshiro Matsui, Tomoyuki Oki, Yutaka Osajima | Requires cookie* | | | Title
| Isolation and Identification of Peptidic a-Glucosidase Inhibitors Derived from Sardine Muscle Hydrolyzate  | | | | Abstract
| We report here the isolation of a-glucosidase (A G H) inhibitory peptides derived from sardine muscle hydrolyzate, which was prepared by digestion with Bacillus licheniformis alka line protease. A s a result of reversed-phase HPLC purification, two A G H inhibitory peptides were isolated from a D EA E -Sephadex A-25 column eluate. The peptides were identified as follows: V al-Trp (IC50 = 22.6 mM) and T ry -T y r -P r o -L e u (IC50 = 3.7 mM). A G H inhibitory studies of T r y -T y r -P r o -L e u and its derivatives demonstrated the importance of the tri peptide chain length as well as the hydrophobic aromatic amino acid tyrosine at the N-terminus, aliphatic amino acids at the C-terminus, as well as an amide proton from the peptide chain at the middle position of the tri-peptide to develop AGH inhibition activity. | | | |
Reference
| Z. Naturforsch. 54c, 259 (1999); received August 25/October 5 1998 | | | |
Published
| 1999 | | | |
Keywords
| a-G lucosidase Inhibition, Diabetes, Sardine Muscle Hydrolyzate, Peptide | | | |
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| default:Reihe_C/54/ZNC-1999-54c-0259.pdf | | | | Identifier
| ZNC-1999-54c-0259 | | | | Volume
| 54 | |
| 2 | Author
| IvankaG. Stankova3, M. Ario, F. Simeonovb, Vera Maximova0, AngelS. Galabov0, EvgenyV. Golovinskyd | Requires cookie* | | | Title
| Synthesis and Anti-Virus Activity of Some Nucleosides Analogues | | | | Abstract
| New 3'-, 5'-, 5-bromo-2'-deoxyuridine (3 a -g) and 3'-, 5'-thymidine (4 a -i) analogues with amino acid and peptide residues were synthesized and evaluated for antiviral activity. The influence of long peptide chains, essential amino acids and the effect of this structural modifi cation on the antiviral activity has been also reported. Three 5-bromo-2'-deoxyuridine derivatives containing glycyl-, glycyl-glycyl-and glycyl-gly-cyl-glycyl-residues (3a, 3b, 3c) showed a strong activity against the herpes virus PsRV and a moderate one vs. HSV-1. The corresponding thymidine analogues were considerably less effective, and only com pounds 4d and 4h showed a borderline effect against PsRV. | | | |
Reference
| Z. Naturforsch. 54c, 75—83 (1999); received August lO/October 20 1998 | | | |
Published
| 1999 | | | |
Keywords
| 5-Bromo-2'-Deoxyuridine, Thymidine, Amino Acids, Peptides, Antiherpes Activity | | | |
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| default:Reihe_C/54/ZNC-1999-54c-0075.pdf | | | | Identifier
| ZNC-1999-54c-0075 | | | | Volume
| 54 | |
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